With the world's population ageing, the incidence of Parkinson's disease (PD) is on the rise.
In recent years, inflammatory processes have emerged as prominent contributors to the …

Over 20 years ago, the synaptic protein α-synuclein was identified as the primary component
of the Lewy bodies (LBs) that are a sine qua non of Parkinson's disease (PD). Since that …

Abstract Parkinson's disease (PD), the second most common age-associated
neurodegenerative disorder, is characterized by the loss of dopaminergic (DA) neurons and …

In December 2019, a pneumonia outbreak associated with a novel form of human
coronavirus was reported in Wuhan, Hubei province, China. 1, 2 As the causative agent of …

Idiopathic Parkinson's disease (iPD) is a movement disorder characterized by the
degeneration of dopaminergic neurons and aggregation of the protein α‐synuclein. Patients …

The past two decades in research has revealed the importance of leucine-rich repeat kinase
2 (LRRK2) in both monogenic and sporadic forms of Parkinson's disease (PD). In families …

Parkinson disease (PD), once considered as a prototype of a sporadic disease, is now
known to be considerably affected by various genetic factors, which interact with …

Missense mutations in leucine-rich repeat kinase 2 (LRRK2) cause late-onset Parkinson's
disease (PD), and common genetic variation in LRRK2 modifies susceptibility to Crohn's …

Mutations associated with leucine-rich repeat kinase 2 are the most common known cause
of Parkinson's disease. The known expression of leucine-rich repeat kinase 2 in immune …

Mutations in the leucine-rich-repeat kinase 2 (LRRK2) gene are associated with familial and
sporadic cases of Parkinson's disease but are also found in immune-related disorders such …