Melanin pigment plays a critical role in the protection against the harmful effects of ultraviolet
radiation and other environmental stressors. It is produced by the enzymatic transformation …

Valosin-containing protein (VCP)/p97, a member of the AAA+ ATPase family, is a molecular
chaperone recruited to the endoplasmic reticulum (ER) membrane by binding to membrane …

Glioblastoma multiforme (GBL) is the most common and aggressive brain neoplasm. A
standard therapeutic approach for GBL involves combination therapy consisting of surgery …

RNA-binding proteins serve an essential role in post-transcriptional gene regulation.
Cytoplasmic activation/proliferation-associated protein-1 (caprin-1) is an RNA-binding …

The focus of the present review is to investigate the role of melanin in the radioprotection of
melanoma and attempts to sensitize tumors to radiation by inhibiting melanogenesis. Early …

α-Actinin-4 (ACTN4), a key regulator of the actin cytoskeleton, is up-regulated in melanoma,
though its role in melanoma remains speculative. We have discovered that in WM1158, a …

Caprin-1 has been found to promotes osteosarcoma tumor growth, lung metastasis in mice,
regulating the proliferation and invasion of human breast cancer cells and up-regulated in …

Cutaneous melanoma (CM) has become a major public health concern. Studies illustrate
that minichromosome maintenance protein 7 (MCM7) participate in various diseases …

Background Human papillomavirus (HPV)‐positive oropharyngeal carcinomas response
better to X‐ray therapy (XRT) than HPV‐negative disease. Whether HPV status influences …

Cellular response to non-lethal radiation stress include perturbations in DNA repair,
angiogenesis, migration, and adhesion, among others. Low-LET proton beam radiation has …