Polymorphic drug-metabolizing enzymes (DMEs) are responsible for the metabolism of the
majority of psychotropic drugs. By explaining a large portion of variability in individual drug …

The metabolism of xenobiotics in human brain constitutes a field of recent intensive research
in relation to the potential implications in the pharmacological effect of drugs acting on the …

CYP2D6 genotype and debrisoquine metabolic ratio (MR) were analyzed in 133
Nicaraguan Mestizos (NMs) and 260 Cubans divided into Cuban Mestizos (CMs) and White …

Quantitative systems pharmacology (QSP) has emerged as a transformative science in drug
discovery and development. It is now time to fully rethink the biological functions of drug …

Debrisoquine hydroxylation polymorphism is by far the most thoroughly studied genetic
polymorphism of the CYP2D6 drug-metabolizing enzyme. Debrisoquine hydroxylation …

Individual and population differences in polymorphic cytochrome P 450 enzyme function
have been known for decades. The biological significance of these differences has now …

Wild type genotypes (CYP2D6) and their allelic variants have been described in a sample of
a Peruvian mestizo population. The global allele frequency was 0.015 for CYP2D6* 3 and …

Objectives: Our group has previously show that interindividual variability in CYP2D6
hydroxylation capacity was related to personality differences in cognitive social anxiety …

Genetic variations within the cytochrome P450 (CYP450) superfamily of drug metabolizing
enzymes confer substantial person-to-person and between-population differences in …

CYP2D6 polymorphisms show large geographical and interethnic differences. Variations in
CYP2D6 activity may impact upon a patient's pain level and may contribute to interindividual …