Pyrazoles are five-membered heterocyclic compounds that contain nitrogen. They are an
important class of compounds for drug development; thus, they have attracted much …

Innate inflammation beyond a threshold is a significant problem involved in cardiovascular
diseases, cancer, and many other chronic conditions. Cyclooxygenase (COX) enzymes are …

To search for effective and selective COX-2 inhibitors, four novel series of tetrazole
derivatives were designed based on bioisosteric replacement of SO 2 NH 2 in celecoxib with …

The development of NSAIDs/iNOS inhibitor hybrids is a new strategy for the treatment of
inflammatory diseases by suppression of the overproduction of PGE 2 and NO. A novel …

Simple Summary Novel pharmacological approaches are needed to improve treatments of
advanced cancers, despite the considerable benefit of immunotherapy. New drugs are …

Carbonic anhydrase (CA) is a metalloenzyme that catalyzes the interconversion between
carbon dioxide and water and dissociated ions of carbonic acid. In addition, CA performs …

As our ongoing work on lathyrane diterpenoid derivatization, three series of lathyrane
diterpenoid derivatives were designed and synthesized based combination principles …

Introduction Bipyrazole is constituted from two pyrazole units either in their fully aromatic or
partially hydrogenated forms. Pyrazoles are widely available in pharmaceutical and …

An efficient and catalyst free protocol has been disclosed for aza-Michael addition reaction
of pyrazoles with 2-aryl-3-nitro-2H-chromene derivatives, which provides synthetically …

Heterocyclic compounds play a crucial role in the drug discovery process and development
due to their significant presence and importance. Here, we report a comprehensive analysis …