Ferroptosis is a non-apoptotic form of regulated cell death characterized by the lethal
accumulation of iron-dependent membrane-localized lipid peroxides. It acts as an innate …

Ferroptosis is programmed cell death induced by iron-driven lipid peroxidation. Numerous
studies have shown that ferroptosis is implicated in the progression of colorectal cancer …

In recent years, the significant impact of lactate in the tumor microenvironment has been
greatly documented. Acting not only as an energy substance in tumor metabolism, lactate is …

High recurrence and metastasis rates and poor prognoses are the major challenges of
current cancer therapy. Mounting evidence suggests that cancer stem cells (CSCs) play an …

Background Primary resistance to anti-EGFR therapies affects 40% of metastatic colorectal
cancer patients harbouring wild-type RAS/RAF. YAP1 activation is associated with this …

Abstract Cyclin-dependent kinase 7 (CDK7) serves as a pivotal regulator in orchestrating
cellular cycle dynamics and gene transcriptional activity. Elevated expression levels of …

Ferroptosis, an iron-dependent form of regulated cell death, is emerging as a crucial
regulator of human physiology and pathology. Increasing evidence showcases a reciprocal …

Esophageal cancer (EC) is one of the most common malignancies worldwide with the
character of poor prognosis and high mortality. Despite significant advancements have been …

Background Cancer stem-like cells (CSCs) play an important role in initiation and
progression of aggressive cancers, including esophageal cancer. Natural killer (NK) cells …

Abnormal metabolism is regarded as an oncogenic hallmark related to tumor progression
and therapeutic resistance. Present study employed multi-omics, including …