Physiological roles of hydrogen sulfide in mammalian cells, tissues, and organs

G Cirino, C Szabo… - Physiological …, 2023 - journals.physiology.org
Over the last two decades, hydrogen sulfide (H2S) has emerged as an endogenous
regulator of a broad range of physiological functions. H2S belongs to the class of molecules …

Nitric oxide signalling in cardiovascular health and disease

C Farah, LYM Michel, JL Balligand - Nature Reviews Cardiology, 2018 - nature.com
Nitric oxide (NO) signalling has pleiotropic roles in biology and a crucial function in
cardiovascular homeostasis. Tremendous knowledge has been accumulated on the …

Emergence of hydrogen sulfide as an endogenous gaseous signaling molecule in cardiovascular disease

DJ Polhemus, DJ Lefer - Circulation research, 2014 - Am Heart Assoc
Long recognized as a malodorous and highly toxic gas, recent experimental studies have
revealed that hydrogen sulfide (H2S) is produced enzymatically in all mammalian species …

Hydrogen sulfide cytoprotective signaling is endothelial nitric oxide synthase-nitric oxide dependent

AL King, DJ Polhemus, S Bhushan… - Proceedings of the …, 2014 - National Acad Sciences
Previous studies have demonstrated that hydrogen sulfide (H2S) protects against multiple
cardiovascular disease states in a similar manner as nitric oxide (NO). H2S therapy also has …

Vascular biology of hydrogen sulfide

NL Kanagy, C Szabo… - American Journal of …, 2017 - journals.physiology.org
Hydrogen sulfide (H2S) is a ubiquitous signaling molecule with important functions in many
mammalian organs and systems. Observations in the 1990s ascribed physiological actions …

Mitochondrial H2S Regulates BCAA Catabolism in Heart Failure

Z Li, H Xia, TE Sharp III, KB LaPenna, JW Elrod… - Circulation …, 2022 - Am Heart Assoc
Background: Hydrogen sulfide (H2S) exerts mitochondria-specific actions that include the
preservation of oxidative phosphorylation, biogenesis, and ATP synthesis, while inhibiting …

Hydrogen sulfide, an enhancer of vascular nitric oxide signaling: mechanisms and implications

C Szabo - American Journal of Physiology-Cell Physiology, 2017 - journals.physiology.org
Nitric oxide (NO) vascular signaling has long been considered an independent, self-
sufficient pathway. However, recent data indicate that the novel gaseous mediator, hydrogen …

Role of hydrogen sulfide in NRF2-and sirtuin-dependent maintenance of cellular redox balance

T Corsello, N Komaravelli, A Casola - Antioxidants, 2018 - mdpi.com
Hydrogen sulfide (H2S) has arisen as a critical gasotransmitter signaling molecule
modulating cellular biological events related to health and diseases in heart, brain, liver …

[HTML][HTML] An updated role of astragaloside IV in heart failure

Y Zang, J Wan, Z Zhang, S Huang, X Liu… - Biomedicine & …, 2020 - Elsevier
Heart failure (HF) has become a worldwide public health problem that seriously threatens
human's health. Due to" multi-target" effect, traditional Chinese medicine (TCM) has unique …

Evolution of hydrogen sulfide therapeutics to treat cardiovascular disease

Z Li, DJ Polhemus, DJ Lefer - Circulation Research, 2018 - Am Heart Assoc
Hydrogen sulfide (H2S)—a potent gaseous signaling molecule—has emerged as a critical
regulator of cardiovascular homeostasis. H2S is produced enzymatically by 3 constitutively …