The human cathelicidin hCAP18/LL-37 has become a paradigm for the pleiotropic roles of
peptides in host defence. It has a remarkably wide functional repertoire that includes direct …

Antimicrobial peptides (AMPs) are ubiquitous, gene-encoded natural antibiotics that have
gained recent attention in the search for new antimicrobials to combat infectious disease. In …

Antimicrobial peptides (AMPs) are molecules with a broad-spectrum activity against
bacteria, fungi, protozoa, and viruses. These peptides are widely distributed in insects …

Activation of the immune system needs to be tightly regulated to provide protection against
infections and, at the same time, to prevent excessive inflammation to limit collateral damage …

Host defense peptides (HDPs) are a large group of innate immune effectors that are also
termed antimicrobial peptides. Because of the rapid progress that has been made in …

Cathelicidins are short cationic peptides initially described as antimicrobial peptides, which
can also modulate the immune system. Because most findings have been described in the …

Alligator mississippiensis (American alligator), a member of order Crocodilia, lives in
bacteria-laden environments but is not often known to succumb to bacterial infections. Their …

Background To overcome the increasing resistance of pathogens to existing antibiotics the
10×'20 Initiative declared the urgent need for a global commitment to develop 10 new …

Recent years have witnessed a surge in interest directed at innate immune mechanisms.
Proper conceptualization of the key elements of innate immunity, however, is still a work in …

Expanding the antifungal drug arsenal for treating Candida infections is crucial in this era of
the rising life expectancy of patients with immunosuppression and comorbidities. Infections …