The accumulation of senescent cells within tissues is a hallmark of the aging process.
Senescent cells are also commonly present in many age-related diseases and in the cancer …

Colorectal cancer (CRC) is a leading cause of morbidity and mortality worldwide. The
majority of CRC deaths are caused by tumor metastasis, even following treatment. There is …

Metabolic disorders are increasing at an alarming rate due to the stressful lifestyle and
inappropriate diet schedule. The unorganized habits influence multiple epigenetic …

Aberrant DNA methylation is a universal feature of cancer. Here, we present a protocol for
generating high-quality genome-scale DNA methylation sequencing data from a variety of …

Melanoma is a disease associated with a very high mutation burden and thus the possibility
of a diverse range of oncogenic mechanisms that allow it to evade therapeutic interventions …

DNA methylation is an epigenetic modification with an established role in both normal
cellular function and mammalian disease. Despite well-characterized associations between …

A central aspect of life-long stem cell function in slow cycling stem cells is the proper
regulation of cellular quiescence. How the quiescent state is achieved, whether all quiescent …