Peptide drugs offer distinct advantages in therapeutics; however, their limited stability and
membrane penetration abilities hinder their widespread application. One strategy to …

Peptide stapling is a strategy for improving the biological properties of peptides. Herein, we
report a novel method for stapling peptides that utilizes bifunctional triazine moieties for two …

The design and synthesis of a series of peptide derivatives based on a short ACE2 α-helix 1
epitope and subsequent [i-i+ 4] stapling of the secondary structure resulted in the …

Medicinal chemistry is constantly searching for new approaches to develop more effective
and targeted therapeutic molecules. The design of peptidomimetics is a promising emerging …

Amino acids with unusual types of chirality and their derivatives have recently attracted
attention as precursors in the synthesis of chiral catalysts and peptide analogues with …

Conformational freedom-restricted peptides, such as stapled peptides, play a crucial role in
the advancement of functional peptide development. We synthesized stapled octapeptides …

Cyclopeptide Synthesis by Ring-Closing Metathesis Page 1 © 2022. Thieme. All rights reserved.
Georg Thieme Verlag KG, Rüdigerstraße 14, 70469 Stuttgart, Germany 565 A. UEDA*, Y …

[背景・目的] タンパク質は 20 種類の L-α-アミノ酸の織りなす多様な配列により構成されており,
生理機能の発現では α-ヘリックス構造が重要である. タンパク質に比べ合成が容易なペプチドは …