Colorectal cancer (CRC) is the third most common cancer type and the second cause of
death worldwide. The advancement in understanding molecular pathways involved in CRC …

Warburg and coworkers' observation of altered glucose metabolism in tumours has been
neglected for several decades, which, in part, was because of an initial misinterpretation of …

Chronic hypoxia is associated with a variety of physiological conditions such as rheumatoid
arthritis, ischemia/reperfusion injury, stroke, diabetic vasculopathy, epilepsy and cancer. At …

Dihydroartemisinin (DHA), an effective antimalarial drug, has been widely investigated as an
anti-tumor agent. Although previous studies have indicated the potential therapeutic effects …

Rucaparib is a potent small-molecule inhibitor of poly (ADP-ribose) polymerase (PARP)
proteins (PARP-1, PARP-2 and PARP-3) that play an important role in repairing DNA …

The effect of mutations in the P53 family of transcription factors on their biological functions,
including partial or complete loss of transcriptional activity, has been confirmed several …

Homologous recombination is a crucial pathway that is specialized in repairing double-
strand breaks; thus, alterations in genes of this pathway may lead to loss of genomic stability …

In this review, we summarize the existing literature on next generation sequencing (NGS)
studies in vulvar squamous cell carcinoma (VSCC). A total of 201 VSCC tumor samples …

The aetiology of developing cancer consists of genetic and epigenetic mutations, DNA
damage, genome instability, cancer stem cells, infectious agents, and carcinogens …

The vast majority of ovarian cancers have a TP53 mutation. Among these, a substantial
proportion also have a BRCA1 and/or a BRCA2 mutation. Given a rising interest in the …