Steroidogenesis, the processes by which cholesterol is converted to steroid hormones,
involves transport proteins, enzymes, redox partners and cofactors. Most steroidogenic …

Significant advances have taken place in our knowledge of the enzymes involved in steroid
hormone biosynthesis since the last comprehensive review in 1988. Major developments …

Epidemiological, migration, intervention, and genetic studies in humans and animals
provide very strong evidence of a causal link between high salt intake and high blood …

Aldosterone, secreted by the adrenal zona glomerulosa, enhances sodium retention, thus
increasing blood volume and pressure. Excessive production of aldosterone results in high …

Aldosterone is the major mineralocorticoid synthesized by the adrenal and plays an
important role in the regulation of systemic blood pressure through the absorption of sodium …

Classically, aldosterone is synthesised in the adrenal zona glomerulosa and binds to
specific mineralocorticoid receptors located in the cytosol of target epithelial cells …

Background—Recent reports have indicated that aldosterone is produced in extra-adrenal
tissues in animals. The present study was designed to examine whether aldosterone is …

The human adrenal cortex is a complex endocrine organ that secretes mineralocorticoids,
glucocorticoids and adrenal androgens. These steroids arise from morphologically and …

Aldosterone, the primary human mineralocorticoid, is a major regulator of intravascular
volume and blood pressure. The capacity of the adrenal gland to produce aldosterone is …

Aldosterone is a steroid hormone synthesized in and secreted from the outer layer of the
adrenal cortex, the zona glomerulosa. Aldosterone is responsible for regulating sodium …