The pancreas is an organ containing two distinct populations of cells, the exocrine cells that
secrete enzymes into the digestive tract, and the endocrine cells that secrete hormones into …

Pancreatic development represents a fascinating process in which two morphologically
distinct tissue types must derive from one simple epithelium. These two tissue types …

The activity of TGF-β1 is regulated primarily extracellularly where the secreted latent form
must be modified to expose the active molecule. Here we show that thrombospondin-1 is …

Determination of signaling pathways that regulate beta-cell replication is critical for beta-cell
therapy. Here, we show that blocking pancreatic macrophage infiltration after pancreatic …

The pancreas emerges independently from dorsal and ventral domains of embryonic gut
endoderm. Gene inactivation experiments in mice have identified factors required for dorsal …

▪ Abstract Endoderm, one of the three principal germ layers, contributes to all organs of the
alimentary tract. For simplicity, this review divides formation of endodermal organs into four …

Pancreatic ductal adenocarcinoma (PDAC) is an almost uniformly lethal disease in humans.
Transforming growth factor-β (TGF-β) signaling plays an important role in PDAC …

Developmental biology has long benefited from studies of classic model organisms.
Recently, human pluripotent stem cells (hPSCs), including human embryonic stem cells and …

Classic studies of dissected and recombined embryonic pancreas tissues published four
decades ago suggested that epithelial–mesenchymal cell interactions regulate growth …

The development of insulin-producing pancreatic beta (β)-cells represents the culmination of
a complex developmental program. Cells of the posterior foregut assume a pancreatic …