Systems biology is a natural extension of molecular biology; it can be defined as biology
after identification of key gene (s). Systems-biological research is a multistage process …

The functioning of many biochemical networks is often robust—remarkably stable under
changes in external conditions and internal reaction parameters. Much recent work on …

A simple negative feedback loop of interacting genes or proteins has the potential to
generate sustained oscillations. However, many biological oscillators also have a positive …

Circadian clocks maintain robust and accurate timing over a broad range of physiological
temperatures, a characteristic termed temperature compensation. In Arabidopsis thaliana …

▪ Abstract Over the course of the past 40 years Neurospora has become a well-known and
uniquely tractable model system for the analysis of the molecular basis of eukaryotic …

Many organisms display rhythms of physiology and behavior that are entrained to the 24-h
cycle of light and darkness prevailing on Earth. Under constant conditions of illumination …

Abstract In the 1960's Brian Goodwin published a couple of mathematical models showing
how feedback inhibition can lead to oscillations and discussed possible implications of this …

In a recent series of ground-breaking experiments, Nakajima et al.[Nakajima M, Imai K, Ito H,
Nishiwaki T, Murayama Y, Iwasaki H, Oyama T, Kondo T (2005) Science 308: 414–415] …

Temperature compensation is a defining feature of circadian oscillators, yet no components
contributing to the phenomenon have been identified in plants. We tested 27 accessions of …

Many species of cold-blooded animals experience substantial and rapid fluctuations in body
temperature. Because biological processes are differentially temperature dependent, it is …