Uncovering mechanisms of brain inflammation in Alzheimer's disease with APOE4: Application of single cell‐type lipidomics
A chronic state of unresolved inflammation in Alzheimer's disease (AD) is intrinsically
involved with the remodeling of brain lipids. This review highlights the effect of carrying the …
involved with the remodeling of brain lipids. This review highlights the effect of carrying the …
Agmatine as a Novel Intervention for Alzheimer's Disease: Pathological Insights and Cognitive Benefits
RA Katariya, SS Sammeta, MB Kale… - Ageing Research …, 2024 - Elsevier
Alzheimer's disease (AD) is a devastating neurodegenerative disorder characterized by
progressive cognitive decline and a significant societal burden. Despite extensive research …
progressive cognitive decline and a significant societal burden. Despite extensive research …
In silico interactions of natural and synthetic compounds with key proteins involved in Alzheimer's disease: prospects for designing new therapeutics compound
ME Shah-Abadi, A Ariaei, F Moradi… - Neurotoxicity …, 2023 - Springer
Memory impairment is a result of multiple factors including amyloid-beta (Aβ) accumulation.
Several receptors are mediated for Aβ transport and signaling. Moreover, blood lipids are …
Several receptors are mediated for Aβ transport and signaling. Moreover, blood lipids are …
Histone deacetylase inhibition mitigates cognitive deficits and astrocyte dysfunction induced by amyloid‐β (Aβ) oligomers
LP Diniz, J Morgado… - British Journal of …, 2024 - Wiley Online Library
Background and Purpose Inhibitors of histone deacetylases (iHDACs) are promising drugs
for neurodegenerative diseases. We have evaluated the therapeutic potential of the new …
for neurodegenerative diseases. We have evaluated the therapeutic potential of the new …
LRRK2 Kinase Inhibition Attenuates Astrocytic Activation in Response to Amyloid β1-42 Fibrils
A Filippini, V Salvi, V Dattilo, C Magri, S Castrezzati… - Biomolecules, 2023 - mdpi.com
Intracerebral accumulation of amyloid-β in the extracellular plaques of Alzheimer's disease
(AD) brains represents the main cause of reactive astrogliosis and neuroinflammatory …
(AD) brains represents the main cause of reactive astrogliosis and neuroinflammatory …
Applications of induced pluripotent stem cell-derived glia in brain disease research and treatment
Z Yang, M Gong, C Yang, C Chen, K Zhang - Human iPSC-derived …, 2023 - Springer
Glia are integral components of neural networks and are crucial in both physiological
functions and pathological processes of the brain. Many brain diseases involve glial …
functions and pathological processes of the brain. Many brain diseases involve glial …
Histone deacetylase inhibition mitigates cognitive deficits and astrocyte dysfunction induced by Aβ oligomers
J Morgado, LP Diniz, APB Araujo, LMS Antônio… - bioRxiv, 2023 - biorxiv.org
Inhibitors of histone deacetylases (iHDACs) are promising drugs for neurodegenerative
diseases. We have evaluated the therapeutic potential of the new iHDAC6 LASSBio-1911 in …
diseases. We have evaluated the therapeutic potential of the new iHDAC6 LASSBio-1911 in …