Ageing is a complex, multifaceted process leading to widespread functional decline that
affects every organ and tissue, but it remains unknown whether ageing has a unifying causal …

In recent decades, chemotherapies targeting apoptosis have emerged and demonstrated
remarkable achievements. However, emerging evidence has shown that chemoresistance is …

Nicotinamide adenine dinucleotide (NAD+) and its metabolites function as critical regulators
to maintain physiologic processes, enabling the plastic cells to adapt to environmental …

B group vitamins represent essential micronutrients for myriad metabolic and regulatory
processes required for human health, serving as cofactors used by hundreds of enzymes …

Germline alterations in many genes coding for proteins regulating DNA repair and DNA
damage response (DDR) to DNA double-strand breaks (DDSB) have been recognized as …

Hepatocellular carcinoma (HCC) is an increasing burden on global public health and is
associated with enhanced lipogenesis, fatty acid uptake, and lipid metabolic …

Inflammation is an adaptive response in pursuit of homeostasis reestablishment triggered by
harmful conditions or stimuli, such as an infection or tissue damage. Liver diseases cause …

Deregulation of protein post-translational modifications is intensively involved in the etiology
of diseases, including degenerative diseases, inflammatory injuries, and cancers …

Living organisms are surrounded with heavy metals such as methylmercury, manganese,
cobalt, cadmium, arsenic, as well as pesticides such as deltamethrin and paraquat, or …

Alcoholism is a widespread and damaging behaviour of people throughout the world. Long-
term alcohol consumption has resulted in alcoholic liver disease (ALD) being the leading …