Biomaterials combined with cell therapy for treatment of spinal cord injury

Š Kubinová, E Syková - Regenerative medicine, 2012 - Taylor & Francis
Spinal cord injury (SCI) is a devastating traumatic injury resulting in paralysis or sensory
deficits due to tissue damage and the poor ability of axons to regenerate across the lesion …

Microfluidic spinning of flat alginate fibers with grooves for cell-aligning scaffolds.

E Kang, YY Choi, SK Chae, JH Moon… - … (Deerfield Beach, Fla …, 2012 - europepmc.org
Alginate microribbons with longitudinally grooved microstructures are continuously
fabricated by means of a microfluidic system. The number and dimensions of the …

[HTML][HTML] Neurotrauma and mesenchymal stem cells treatment: From experimental studies to clinical trials

AMB Martinez, C de Oliveira Goulart… - World Journal of Stem …, 2014 - ncbi.nlm.nih.gov
Mesenchymal stem cell (MSC) therapy has attracted the attention of scientists and clinicians
around the world. Basic and pre-clinical experimental studies have highlighted the positive …

Evaluation of spinal cord injury animal models

N Zhang, M Fang, H Chen, F Gou… - Neural regeneration …, 2014 - journals.lww.com
Because there is no curative treatment for spinal cord injury, establishing an ideal animal
model is important to identify injury mechanisms and develop therapies for individuals …

Stem cell transplantation for spinal cord injury: a meta-analysis of treatment effectiveness and safety

X Fan, J Wang, X Lin, L Zhang - Neural regeneration research, 2017 - journals.lww.com
OBJECTIVE: The aim of this study was to evaluate the effectiveness and safety of stem cell
transplantation for spinal cord injury (SCI). DATA SOURCES: PubMed, EMBASE, Cochrane …

Tissue engineered regeneration of completely transected spinal cord using human mesenchymal stem cells

KN Kang, SM Yoon, JY Lee, BN Lee, JS Kwon… - Biomaterials, 2012 - Elsevier
The present study employed a combinatorial strategy using poly (d, l-lactide-co-
glycolide)(PLGA) scaffolds seeded with human mesenchymal stem cells (hMSCs) to …

Effects of phosphate glass fiber–collagen scaffolds on functional recovery of completely transected rat spinal cords

NY Joo, JC Knowles, GS Lee, JW Kim, HW Kim… - Acta biomaterialia, 2012 - Elsevier
Phosphate-based glass fibers (PGFs), due to characteristics such as biodegradability and
directionality, could be effective as spatial cues for axonal outgrowth following nerve injury …

Local delivery of high-dose chondroitinase ABC in the sub-acute stage promotes axonal outgrowth and functional recovery after complete spinal cord transection

CH Cheng, CT Lin, MJ Lee, MJ Tsai, WH Huang… - PloS one, 2015 - journals.plos.org
Chondroitin sulfate proteoglycans (CSPGs) are glial scar-associated molecules considered
axonal regeneration inhibitors and can be digested by chondroitinase ABC (ChABC) to …

Clinical and experimental advances in regeneration of spinal cord injury

JK Hyun, HW Kim - Journal of tissue engineering, 2010 - journals.sagepub.com
Spinal cord injury (SCI) is one of the major disabilities dealt with in clinical rehabilitation
settings and is multifactorial in that the patients suffer from motor and sensory impairments …

A proposal for a rat model of spinal cord injury featuring the rubrospinal tract and its contributions to locomotion and skilled hand movement

R Morris, IQ Whishaw - Frontiers in neuroscience, 2016 - frontiersin.org
Spinal cord injury and repair is a dynamic field of research. The development of reliable
animal models of traumatic spinal cord injury has been invaluable in providing a wealth of …