Candida albicans is a commensal yeast fungus of the human oral, gastrointestinal, and
genital mucosal surfaces, and skin. Antibiotic-induced dysbiosis, iatrogenic …

Heterozygous gain-of-function (GOF) mutations in STAT1 in patients with chronic
mucocutaneous candidiasis (CMC) and hypothyroidism were discovered in 2011. CMC is …

The discovery of the autoimmune regulator (AIRE) protein and the delineation of its critical
contributions in the establishment of central immune tolerance has significantly expanded …

Background: Germline mutations in signal transducer and activator of transcription 1
(STAT1), which lead to primary immunodeficiency, are classified as defects in intrinsic and …

STAT1 dysfunction causes a wide range of immune dysregulation phenotypes, which have
been classified into four disease types, namely,(i) autosomal recessive (AR) complete …

Germline human heterozygous STAT1 gain‐of‐function (GOF) variants were first discovered
a common cause of chronic mucocutaneous candidiasis (CMC) in 2011. Since then …

Mutations in the coiled-coil and DNA-binding domains of STAT1 lead to delayed STAT1
dephosphorylation and subsequently gain-of-function. The associated clinical phenotype is …

Abstract Purpose Heterozygous STAT1 Gain-of-Function (GOF) mutations are the most
common cause of chronic mucocutaneous candidiasis (CMC) among Inborn Errors of …

Bacille Calmette–Guerin (BCG) vaccine is widely used as a prevention strategy against
tuberculosis. BCG is a live vaccine, usually given early in life in most countries. While safe to …

Nasopharyngeal carcinoma (NPC) is the most common nasopharyngeal squamous cell
carcinoma, and recurrence and metastasis are still difficult problems in its current treatment …