There is a growing interest in understanding tissue organization, homeostasis, and
inflammation. However, despite an abundance of data, the organizing principles of tissue …

Dopamine (DA) is a key neurotransmitter involved in multiple physiological functions
including motor control, modulation of affective and emotional states, reward mechanisms …

Class A G-protein-coupled receptors (GPCRs) influence virtually every aspect of human
physiology. Understanding receptor activation mechanism is critical for discovering novel …

Trace amines are endogenous compounds classically regarded as comprising β-
phenylethyalmine, p-tyramine, tryptamine, p-octopamine, and some of their metabolites …

Bone has recently emerged as a pleiotropic endocrine organ that secretes at least two
hormones, FGF23 and osteocalcin, which regulate kidney function and glucose …

The variety of physiological functions controlled by dopamine in the brain and periphery is
mediated by the D 1, D 2, D 3, D 4 and D 5 dopamine GPCRs. Drugs acting on dopamine …

Involuntary movements, or dyskinesia, represent a debilitating complication of levodopa (L-
dopa) therapy for Parkinson's disease (PD). L-dopa-induced dyskinesia (LID) are ultimately …

G protein-coupled dopamine receptors (D1, D2, D3, D4, and D5) mediate all of the
physiological functions of the catecholaminergic neurotransmitter dopamine, ranging from …

A long-held tenet of molecular pharmacology is that canonical signal transduction mediated
by G-protein-coupled receptor (GPCR) coupling to heterotrimeric G proteins is confined to …

Despite the discovery of heterotrimeric αβγ G proteins∼ 25 years ago, their selective
perturbation by cell-permeable inhibitors remains a fundamental challenge. Here we report …