Kidney damage varies according to the primary insult. Different aetiologies of acute kidney
injury (AKI), including kidney ischaemia, exposure to nephrotoxins, dehydration or sepsis …

Perioperative hypotension is common and associated with poor outcomes, including acute
kidney injury (AKI). The mechanistic link between perioperative hypotension and AKI is at …

Acute kidney injury (AKI) is common in the critically ill. Inadequate renal medullary tissue
oxygenation has been linked to its pathogenesis. Moreover, renal medullary tissue hypoxia …

Agonists of α2‐adrenoceptors are increasingly being used for the provision of comfort,
sedation and the management of delirium in critically ill patients, with and without sepsis. In …

Renal tissue hypoxia has been implicated as a critical mediatory factor in multiple forms of
acute kidney injury (AKI), including in sepsis. In sepsis, whole-kidney measures of …

Acute kidney injury (AKI) is a common and serious post‐operative complication of cardiac
surgery. The value of a predictive biomarker is determined not only by its predictive efficacy …

Objectives Poor medullary oxygenation is implicated in the evolution of acute kidney injury.
The authors sought to determine if increasing systemic flow and mean arterial pressure …

Renal medullary hypoxia may contribute to the pathophysiology of acute kidney injury,
including that associated with cardiac surgery requiring cardiopulmonary bypass (CPB) …

Aim Renal tissue hypoxia during cardiopulmonary bypass could contribute to the
pathophysiology of acute kidney injury. We tested whether renal tissue hypoxia can be …

Aim Blood transfusion may improve renal oxygenation during cardiopulmonary bypass
(CPB). In an ovine model of experimental CPB, we tested whether increasing blood …