Research approaches for studying flow-induced thromboembolic complications in blood recirculating devices

D Bluestein - Expert review of medical devices, 2004 - Taylor & Francis
The advent of implantable blood recirculating devices has provided life-saving solutions to
patients with severe cardiovascular diseases. Recently it has been reported that ventricular …

Review of numerical methods for simulation of mechanical heart valves and the potential for blood clotting

MS Zakaria, F Ismail, M Tamagawa, AFA Aziz… - Medical & biological …, 2017 - Springer
Even though the mechanical heart valve (MHV) has been used routinely in clinical practice
for over 60 years, the occurrence of serious complications such as blood clotting remains to …

Characterization of hemodynamic forces induced by mechanical heart valves: Reynolds vs. viscous stresses

L Ge, LP Dasi, F Sotiropoulos… - Annals of biomedical …, 2008 - Springer
Bileaflet mechanical heart valves (BMHV) are widely used to replace diseased heart valves.
Implantation of BMHV, however, has been linked with major complications, which are …

A blood-mimicking fluid for particle image velocimetry with silicone vascular models

MY Yousif, DW Holdsworth, TL Poepping - Experiments in fluids, 2011 - Springer
For accurate particle image velocimetry measurements in hemodynamics studies, it is
important to use a fluid with a refractive index (n) matching that of the vascular models …

Free emboli formation in the wake of bi-leaflet mechanical heart valves and the effects of implantation techniques

D Bluestein, YM Li, IB Krukenkamp - Journal of biomechanics, 2002 - Elsevier
The high incidence of thromboembolic complications of mechanical heart valves (MHV),
primarily due to platelet activation by contact with foreign surfaces and by non-physiological …

High-resolution fluid–structure interaction simulations of flow through a bi-leaflet mechanical heart valve in an anatomic aorta

I Borazjani, L Ge, F Sotiropoulos - Annals of biomedical engineering, 2010 - Springer
We have performed high-resolution fluid–structure interaction simulations of physiologic
pulsatile flow through a bi-leaflet mechanical heart valve (BMHV) in an anatomically realistic …

[图书][B] Vortex formation in the heart

A Kheradvar, G Pedrizzetti, A Kheradvar, G Pedrizzetti - 2012 - Springer
The presence of vortical flow structures that develop inside different cardiac chambers is
shown to correlate with functional status of heart, and significantly affects the cardiac …

Flow structure in healthy and pathological left ventricles with natural and prosthetic mitral valves

V Meschini, MD De Tullio, G Querzoli… - Journal of fluid …, 2018 - cambridge.org
In this paper, the structure and the dynamics of the flow in the left heart ventricle are studied
for different pumping efficiencies and mitral valve types (natural, biological and mechanical …

[HTML][HTML] Intravascular hemolysis in patients with new-generation prosthetic heart valves: a prospective study

G Mecozzi, AD Milano, M De Carlo, F Sorrentino… - The Journal of thoracic …, 2002 - Elsevier
Objective: A prospective clinical study was designed to assess the frequency and severity of
intravascular hemolysis in patients with new-generation, normally functioning prosthetic …

[PDF][PDF] Flow-induced platelet activation in a mechanical heart valve

D Bluestein, W Yin, K Affeld, J Jesty - Journal of Heart Valve …, 2004 - researchgate.net
Methods: The procoagulant activity of platelets was measured using a real-time assay of
platelet activation state (PAS), which was based on a modification of the prothrombinase …