The liver X receptors (LXRs) are pivotal regulators of lipid homeostasis in mammals. These
transcription factors control the expression of a battery of genes involved in the uptake …

Atherosclerosis, the pathological basis of most cardiovascular disease (CVD), is closely
associated with cholesterol accumulation in the arterial intima. Excessive cholesterol is …

Epidemiologic studies detected an inverse relationship between HDL (high-density
lipoprotein) cholesterol (HDL-C) levels and atherosclerotic cardiovascular disease …

Liver X receptors (LXRs) are ligand-activated transcription factors of the nuclear receptor
superfamily. There are two LXR isoforms termed α and ß which upon activation form …

Atherosclerosis is a leading cause of cardiovascular disease worldwide, and
hypercholesterolemia is a major risk factor. Preventive treatments mainly focus on the …

Both alterations of lipid/lipoprotein metabolism and inflammatory events contribute to the
formation of the atherosclerotic plaque, characterized by the accumulation of abnormal …

Several steps of the HDL-mediated reverse cholesterol transport (RCT) are transcriptionally
regulated by the nuclear receptors LXRs in the macrophages, liver, and intestine. Systemic …

Most types of cells in the body have no or very limited capacity of catabolizing cholesterol, so
cholesterol efflux is essential for cholesterol homeostasis. There are multiple mechanisms …

Multiple sclerosis (MS) is a chronic neurological disease driven by autoimmune,
inflammatory and neurodegenerative processes leading to neuronal demyelination and …

The discovery of adipose triglyceride lipase (ATGL) and its coactivator comparative gene
identification-58 (CGI-58) provided a major paradigm shift in the understanding of …