There is increasing recognition of the crucial role of the right ventricle (RV) in determining
functional status and prognosis in multiple conditions. The normal RV is anatomically and …

Cardiac remodeling is defined as a group of molecular, cellular and interstitial changes that
manifest clinically as changes in size, mass, geometry and function of the heart after injury …

The world population continues to grow older rapidly, mostly because of declining fertility
and increasing longevity. Since age represents the largest risk factor for cardiovascular …

How cells become specialized, or" mature," is important for cell and developmental biology.
While maturity is usually deemed a terminal fate, it may be more helpful to consider …

With ageing, the potency of individual risk factors traditionally associated with common
illnesses declines. Instead, it is becoming clear that the impact of a wide range of age …

The tricarboxylic acid (TCA) cycle is the main source of cellular energy and participates in
many metabolic pathways in cells. Recent reports indicate that dysfunction of TCA cycle …

Abstract “Inside every old person is a young person wondering what happened.” So, what is
aging? Aging is a manifestation of progressive, time-dependent failure of molecular …

Doxorubicin (DOX) is one of the most effective antineoplastic drugs. However, its clinical
application has been greatly limited due to the development of cardiotoxicity with DOX …

In cardiomyocytes, invaginations of the sarcolemmal membrane called t-tubules are critically
important for triggering contraction by excitation-contraction (EC) coupling. These structures …

Medical advances and the availability of diagnostic tools have considerably increased life
expectancy and, consequently, the elderly segment of the world population. As age is a …