Introduction: Perioperative anesthesia delivers pre-, intra-, and postoperative care to meet
the needs of patients undergoing diagnostic and surgical procedures. Major challenges are …

How general anesthetics work remains a topic of ongoing study. A parallel field of research
has sought to identify methods to reverse general anesthesia. Reversal agents could …

Background and Purpose In addition to binding to the classical high‐affinity extracellular
benzodiazepine binding site of the GABAA receptor, some benzodiazepines occupy …

Increasing ambient pressure has been suggested to reverse general anaesthesia and
provides support for the 'lipid theory'. Anaesthetic dissolution into cell membranes is said to …

Background: The degree to which different volatile anesthetics depress carotid body hypoxic
response relates to their ability to activate TASK potassium channels. Most commonly …

Background: Recent cryo-electron microscopic imaging studies have shown that in addition
to binding to the classical extracellular benzodiazepine binding site of the α1β3γ2L γ …

Background: Naphthalene-etomidate, an etomidate analog containing a bulky phenyl ring
substituent group, possesses very low γ-aminobutyric acid type A (GABAA) receptor efficacy …

Despite their frequent use across many clinical settings, general anesthetics are
medications with lethal side effects and no reversal agents. A fluorinated analogue of …

目的利用膜电位检测原理, 构建一种靶向γ-氨基丁酸A 型受体(GABAAR) 的药物高通量筛选模型.
方法采用α1β2γ2L-GABAAR-CHO 细胞株构建GABAAR 药物高通量筛选方法; …

Background Many sedative-hypnotic agents are thought to act by positively modulating γ-
aminobutyric acid type A (GABA A) receptors. However, for many agents, the location (s) of …