Compared with traditional de novo drug discovery, drug repurposing has become an
attractive drug discovery strategy due to its low-cost and high efficiency. Through a …

The nuclear receptor PPARγ is a ligand-activated transcription factor that plays an important
role in the control of gene expression linked to a variety of physiological processes. PPARγ …

Adipose tissue is an important metabolic organ, the dysfunction of which is associated with
the development of obesity, diabetes mellitus, and cardiovascular disease. The nuclear …

PPARγ is required for fat cell development and is the molecular target of antidiabetic
thiazolidinediones (TZDs), which exert insulin-sensitizing effects in adipose tissue, skeletal …

Studies have emphasized an antineoplastic effect of the non-psychoactive, phyto-
cannabinoid, Cannabidiol (CBD). However, the molecular mechanism underlying its …

Peroxisome proliferator-activated receptors (PPARs) are ligand activated transcription
factors that modulate target gene expression in response to endogenous and exogenous …

The peroxisome proliferator-activated receptors (PPARs) are a family of transcription factors
involved in varied and diverse processes such as steroidogenesis, angiogenesis, tissue …

Introduction: Peroxisome proliferator activated receptor γ (PPARγ) is expressed in epithelial
cells, macrophage, and T and B lymphocytes. Ligand induced activation of PPARγ was …

The epidermis is a very active site of lipid metabolism, and all peroxisome proliferator-
activated receptor (PPAR) and liver X receptor (LXR) isoforms are expressed in the …

The PPAR-gamma (PPAR-γ) activating thiazolidinedione (TZD) medications are a class of
drugs used to improve lipid and glucose metabolism in type-2 diabetes. In addition to their …