Epigenetic tools (The Writers, The Readers and The Erasers) and their implications in cancer therapy
S Biswas, CM Rao - European journal of pharmacology, 2018 - Elsevier
Addition of chemical tags on the DNA and modification of histone proteins impart a distinct
feature on chromatin architecture. With the advancement in scientific research, the key …
feature on chromatin architecture. With the advancement in scientific research, the key …
Epigenetics in cancer: fundamentals and beyond
S Biswas, CM Rao - Pharmacology & Therapeutics, 2017 - Elsevier
Activation of oncogenes or the deactivation of tumor suppressor genes has long been
established as the fundamental mechanism leading towards carcinogenesis. Although this …
established as the fundamental mechanism leading towards carcinogenesis. Although this …
Writers and readers of histone acetylation: structure, mechanism, and inhibition
R Marmorstein, MM Zhou - Cold Spring Harbor …, 2014 - cshperspectives.cshlp.org
Histone acetylation marks are written by histone acetyltransferases (HATs) and read by
bromodomains (BrDs), and less commonly by other protein modules. These proteins …
bromodomains (BrDs), and less commonly by other protein modules. These proteins …
Metabolic and cellular compartments of acetyl-CoA in the healthy and diseased brain
A Jankowska-Kulawy, J Klimaszewska-Łata… - International Journal of …, 2022 - mdpi.com
The human brain is characterised by the most diverse morphological, metabolic and
functional structure among all body tissues. This is due to the existence of diverse neurons …
functional structure among all body tissues. This is due to the existence of diverse neurons …
Targeting triple-negative breast cancer with combination therapy of EGFR CAR T cells and CDK7 inhibition
L Xia, Z Zheng, J Liu, Y Chen, J Ding, G Hu, Y Hu… - Cancer immunology …, 2021 - AACR
EGFR-targeted chimeric antigen receptor (CAR) T cells are potent and specific in
suppressing the growth of triple-negative breast cancer (TNBC) in vitro and in vivo …
suppressing the growth of triple-negative breast cancer (TNBC) in vitro and in vivo …
KAT5 acetylates cGAS to promote innate immune response to DNA virus
ZM Song, H Lin, XM Yi, W Guo… - Proceedings of the …, 2020 - National Acad Sciences
The DNA sensor cGMP-AMP synthase (cGAS) senses cytosolic microbial or self DNA to
initiate a MITA/STING-dependent innate immune response. cGAS is regulated by various …
initiate a MITA/STING-dependent innate immune response. cGAS is regulated by various …
SlSNAT interacts with HSP40, a molecular chaperone, to regulate melatonin biosynthesis and promote thermotolerance in tomato
X Wang, H Zhang, Q Xie, Y Liu, H Lv… - Plant and Cell …, 2020 - academic.oup.com
The SNAT enzyme participates in the biosynthesis of melatonin, which is reported to
regulate thermotolerance in many plants. However, the mechanistic basis of this regulation …
regulate thermotolerance in many plants. However, the mechanistic basis of this regulation …
[HTML][HTML] Small molecule inhibitors of histone acetyltransferases and deacetylases are potential drugs for inflammatory diseases
Highlights•Lysine acetylation 'crosstalks' with other post-translational modifications.•HAT
inhibitors enter the stage as anti-inflammatory agents.•HDAC inhibitors gain increasing …
inhibitors enter the stage as anti-inflammatory agents.•HDAC inhibitors gain increasing …
Histone acetyltransferases are crucial regulators in NF-κB mediated inflammation
Post-translational modifications of proteins, such as acetylation, are important regulatory
events in eukaryotic cells. Reversible acetylations of histones and non-histone proteins …
events in eukaryotic cells. Reversible acetylations of histones and non-histone proteins …