Building Digital Twins for Cardiovascular Health: from principles to clinical impact
The past several decades have seen rapid advances in diagnosis and treatment of
cardiovascular diseases and stroke, enabled by technological breakthroughs in imaging …
cardiovascular diseases and stroke, enabled by technological breakthroughs in imaging …
Cardiovascular models for personalised medicine: Where now and where next?
DR Hose, PV Lawford, W Huberts, LR Hellevik… - Medical engineering & …, 2019 - Elsevier
The aim of this position paper is to provide a brief overview of the current status of
cardiovascular modelling and of the processes required and some of the challenges to be …
cardiovascular modelling and of the processes required and some of the challenges to be …
Inverse problems in blood flow modeling: A review
D Nolte, C Bertoglio - International journal for numerical …, 2022 - Wiley Online Library
Mathematical and computational modeling of the cardiovascular system is increasingly
providing non‐invasive alternatives to traditional invasive clinical procedures. Moreover, it …
providing non‐invasive alternatives to traditional invasive clinical procedures. Moreover, it …
Computational modeling of ventricular-ventricular interactions suggest a role in clinical conditions involving heart failure
Introduction: The left (LV) and right (RV) ventricles are linked biologically, hemodynamically,
and mechanically, a phenomenon known as ventricular interdependence. While LV function …
and mechanically, a phenomenon known as ventricular interdependence. While LV function …
[HTML][HTML] Parameter estimation for closed-loop lumped parameter models of the systemic circulation using synthetic data
NL Bjørdalsbakke, JT Sturdy, DR Hose… - Mathematical …, 2022 - Elsevier
Physics-based models can be applied to describe mechanisms in both health and disease,
which has the potential to accelerate the development of personalized medicine. The aim of …
which has the potential to accelerate the development of personalized medicine. The aim of …
[HTML][HTML] Bridging the gap between measurements and modelling: a cardiovascular functional avatar
Lumped parameter models of the cardiovascular system have the potential to assist
researchers and clinicians to better understand cardiovascular function. The value of such …
researchers and clinicians to better understand cardiovascular function. The value of such …
Kinetic scheme for arterial and venous blood flow, and application to partial hepatectomy modeling
The article introduces a kinetic scheme to solve the 1D Euler equations of hemodynamics,
and presents comparisons of a closed-loop 1D–0D model with real measurements obtained …
and presents comparisons of a closed-loop 1D–0D model with real measurements obtained …
A method of parameter estimation for cardiovascular hemodynamics based on deep learning and its application to personalize a reduced‐order model
Y Zhou, Y He, J Wu, C Cui, M Chen… - International Journal for …, 2022 - Wiley Online Library
Precise model personalization is a key step towards the application of cardiovascular
physical models. In this manuscript, we propose to use deep learning (DL) to solve the …
physical models. In this manuscript, we propose to use deep learning (DL) to solve the …
Object‐Oriented Lumped‐Parameter Modeling of the Cardiovascular System for Physiological and Pathophysiological Conditions
In this work, a lumped‐parameter Windkessel model of the cardiovascular system that
simulates biomechanical parameters of the human physiology is presented. The object …
simulates biomechanical parameters of the human physiology is presented. The object …
[HTML][HTML] Personalised parameter estimation of the cardiovascular system: Leveraging data assimilation and sensitivity analysis
Detailed models of dynamical systems used in the life sciences may include hundreds of
state variables and many input parameters, often with physical meanings. Therefore …
state variables and many input parameters, often with physical meanings. Therefore …