Resistance to therapy is the major hurdle in the current cancer management. Cancer cells
often rewire their cellular process to alternate mechanisms to resist the deleterious effect …

Colorectal cancer (CRC) is the fourth leading cause of the worldwide cancer mortality.
Different molecular mechanisms have been attributed to the development and progress of …

Ovarian cancer is the leading cause of gynecological cancer-related death. Drug resistance
is the bottleneck in ovarian cancer treatment. The increasing use of novel drugs in clinical …

Aberrant Notch signaling profoundly affects cancer progression. Especially the Notch3
receptor was found to be dysregulated in cancer, where its expression is correlated with …

The Notch family is a highly conserved gene group that regulates cell‐cell interaction,
embryogenesis, and tissue commitment. This review article focuses on the third Notch family …

The Notch signalling pathway is involved in the new vessel formation process by regulating
tip and stalk cells, which are key cells in the sprout formation. This process is essential in …

Notch and Hedgehog signaling are involved in cancer biology and pathology, including the
maintenance of tumor cell proliferation, cancer stem-like cells, and the tumor …

Ovarian cancer is the most lethal of all gynecologic malignancies because women
commonly present with advanced stage disease and develop chemotherapy refractory …

Background Increasing evidence has demonstrated that Notch signaling is deregulated in
human hematological malignancies and solid tumors. This signaling has a protumorigenic …

Purpose A phase II study was performed to evaluate the efficacy and safety of single-agent
RO4929097 (a gamma-secretase inhibitor) in patients with recurrent platinum-resistant …