Cell traction force plays a critical role in directing cellular functions, such as proliferation,
migration, and differentiation. Current understanding of cell traction force is largely derived …

Blood vessel chips are bioengineered microdevices, consisting of biomaterials, human cells,
and microstructures, which recapitulate essential vascular structure and physiology and …

Atomic force microscopy (AFM) provides a platform for high-resolution topographical
imaging and the mechanical characterization of a wide range of samples, including live …

Background Blood platelets have evolved a complex mechanotransduction machinery to
rapidly respond to hemodynamic conditions. A variety of microfluidic flow-based approaches …

Monitoring mechanical stresses in microchannels is challenging. Herein, we report the
development of a mechanofluorescence sensor system featuring a fluorogenic single …

Platelet function tests are essential to profile platelet dysfunction and dysregulation in
hemostasis and thrombosis. Clinically they provide critical guidance to the patient …

Platelets play vital roles in vascular repair, especially in primary hemostasis, and have been
widely used in transfusion to prevent bleeding or manage active bleeding. Recently …

Monitoring platelet aggregation is crucial for predicting thrombotic diseases and identifying
the risk of bleeding or resistance to antiplatelet drugs. This study developed a microfluidic …

Cells sense various environmental cues and subsequently process intracellular signals to
decide their migration direction in many physiological and pathological processes. Although …

Cells interact with the extracellular matrix (ECM) mechanically to perform essential cell
function including migration, proliferation and differentiation, which are critical in …