MicroRNAs, the non-coding single-stranded RNA of 19–25 nucleotides are emerging as
robust players of gene regulation. Plethora of evidences support that the ability of …

The human SH-SY5Y neuroblastoma cell line is widely used in neuroscience research as a
neuronal cell model. Following differentiation to a neuron-like state, SH-SY5Y cells become …

Abstract Human SH-SY5Y neuroblastoma cells maintain their potential for differentiation and
regression in culture conditions. The induction of differentiation could serve as a strategy to …

Neuroblastoma, a progressive solid tumor in childhood, continues to be a clinical challenge.
It is highly vascular, heterogeneous, and extracranial tumor that originates from neural crest …

MicroRNAs are a class of sophisticated regulators of gene expression, acting as post-
transcriptional inhibitors that recognize their target mRNAs through base pairing with short …

Retinoic acid (RA) is used in differentiation therapy to treat a variety of cancers including
neuroblastoma. The contributing factors for its therapeutic efficacy are poorly understood …

The mouse haematopoietic stem cell (SC) regulator Latexin (LXN) is the only known
homologue of the retinoic acid receptor responder 1 (RARRES1) gene. Both genes lie …

Background Nucleolin expressed at the cell surface is a binding protein for a variety of
ligands implicated in tumorigenesis and angiogenesis. By using a specific antagonist that …

FOXP2 was the first gene shown to cause a Mendelian form of speech and language
disorder. Although developmentally expressed in many organs, loss of a single copy of …

Breast cancer is the most common malignancy in women and the appearance of distant
metastases produces the death in 98% of cases. The retinoic acid receptor β (RAR β) is not …