The causes of evolvability and their evolution

JL Payne, A Wagner - Nature Reviews Genetics, 2019 - nature.com
Evolvability is the ability of a biological system to produce phenotypic variation that is both
heritable and adaptive. It has long been the subject of anecdotal observations and …

Epistasis—the essential role of gene interactions in the structure and evolution of genetic systems

PC Phillips - Nature Reviews Genetics, 2008 - nature.com
Epistasis, or interactions between genes, has long been recognized as fundamentally
important to understanding the structure and function of genetic pathways and the …

The genetic landscape of a cell

M Costanzo, A Baryshnikova, J Bellay, Y Kim… - science, 2010 - science.org
A genome-scale genetic interaction map was constructed by examining 5.4 million gene-
gene pairs for synthetic genetic interactions, generating quantitative genetic interaction …

[图书][B] Geometric morphometrics for biologists: a primer

M Zelditch, DL Swiderski, HD Sheets - 2012 - books.google.com
The first edition of Geometric Morphometrics for Biologists has been the primary resource for
teaching modern geometric methods of shape analysis to biologists who have a stronger …

Adaptation to an extraordinary environment by evolution of phenotypic plasticity and genetic assimilation

R Lande - Journal of evolutionary biology, 2009 - academic.oup.com
Adaptation to a sudden extreme change in environment, beyond the usual range of
background environmental fluctuations, is analysed using a quantitative genetic model of …

Biological robustness

H Kitano - Nature Reviews Genetics, 2004 - nature.com
Robustness is a ubiquitously observed property of biological systems. It is considered to be
a fundamental feature of complex evolvable systems. It is attained by several underlying …

Stability effects of mutations and protein evolvability

N Tokuriki, DS Tawfik - Current opinion in structural biology, 2009 - Elsevier
The past several years have seen novel insights at the interface of protein biophysics and
evolution. The accepted paradigm that proteins can tolerate nearly any amino acid …

Computational systems biology

H Kitano - Nature, 2002 - nature.com
To understand complex biological systems requires the integration of experimental and
computational research—in other words a systems biology approach. Computational …

[HTML][HTML] Evolvability as a function of purifying selection in TEM-1 β-lactamase

MA Stiffler, DR Hekstra, R Ranganathan - Cell, 2015 - cell.com
Evolvability—the capacity to generate beneficial heritable variation—is a central property of
biological systems. However, its origins and modulation by environmental factors have not …

Evolution of virulence in opportunistic pathogens: generalism, plasticity, and control

SP Brown, DM Cornforth, N Mideo - Trends in microbiology, 2012 - cell.com
Standard virulence evolution theory assumes that virulence factors are maintained because
they aid parasitic exploitation, increasing growth within and/or transmission between hosts …