TRPM channels in human diseases
The transient receptor potential melastatin (TRPM) subfamily belongs to the TRP cation
channels family. Since the first cloning of TRPM1 in 1989, tremendous progress has been …
channels family. Since the first cloning of TRPM1 in 1989, tremendous progress has been …
Role of TRPM7 in cancer: potential as molecular biomarker and therapeutic target
NS Yee - Pharmaceuticals, 2017 - mdpi.com
The transient receptor potential melastatin-subfamily member 7 (TRPM7) is a ubiquitously
expressed ion channel with intrinsic kinase activity. Molecular and electrophysiological …
expressed ion channel with intrinsic kinase activity. Molecular and electrophysiological …
The fluid shear stress sensor TRPM7 regulates tumor cell intravasation
Tumor cell intravasation preferentially occurs in regions of low fluid shear because high
shear is detrimental to tumor cells. Here, we describe a molecular mechanism by which cells …
shear is detrimental to tumor cells. Here, we describe a molecular mechanism by which cells …
Structural mechanisms of TRPM7 activation and inhibition
KD Nadezhdin, L Correia, C Narangoda… - Nature …, 2023 - nature.com
The transient receptor potential channel TRPM7 is a master regulator of the organismal
balance of divalent cations that plays an essential role in embryonic development, immune …
balance of divalent cations that plays an essential role in embryonic development, immune …
TRPM7 is the central gatekeeper of intestinal mineral absorption essential for postnatal survival
L Mittermeier, L Demirkhanyan… - Proceedings of the …, 2019 - National Acad Sciences
Zn2+, Mg2+, and Ca2+ are essential minerals required for a plethora of metabolic processes
and signaling pathways. Different categories of cation-selective channels and transporters …
and signaling pathways. Different categories of cation-selective channels and transporters …
The molecular appearance of native TRPM7 channel complexes identified by high-resolution proteomics
A Kollewe, V Chubanov, FT Tseung, L Correia… - Elife, 2021 - elifesciences.org
The transient receptor potential melastatin-subfamily member 7 (TRPM7) is a ubiquitously
expressed membrane protein consisting of ion channel and protein kinase domains. TRPM7 …
expressed membrane protein consisting of ion channel and protein kinase domains. TRPM7 …
Leptin induces hypertension acting on transient receptor potential melastatin 7 channel in the carotid body
MK Shin, CC Eraso, YP Mu, C Gu, BHY Yeung… - Circulation …, 2019 - Am Heart Assoc
Rationale: Obesity leads to resistant hypertension and mechanisms are poorly understood,
but high plasma levels of leptin have been implicated. Leptin increases blood pressure …
but high plasma levels of leptin have been implicated. Leptin increases blood pressure …
TRPM6 and TRPM7 differentially contribute to the relief of heteromeric TRPM6/7 channels from inhibition by cytosolic Mg2+ and Mg·ATP
S Ferioli, S Zierler, J Zaißerer, J Schredelseker… - Scientific reports, 2017 - nature.com
TRPM6 and its homologue TRPM7 are α-kinase-coupled divalent cation-selective channels
activated upon reduction of cytosolic levels of Mg2+ and Mg· ATP. TRPM6 is vital for …
activated upon reduction of cytosolic levels of Mg2+ and Mg· ATP. TRPM6 is vital for …
A TRPM7 mutation linked to familial trigeminal neuralgia: Omega current and hyperexcitability of trigeminal ganglion neurons
Trigeminal neuralgia (TN) is a unique pain disorder characterized by intense paroxysmal
facial pain within areas innervated by the trigeminal nerve. Although most cases of TN are …
facial pain within areas innervated by the trigeminal nerve. Although most cases of TN are …
Structural mechanism of TRPM7 channel regulation by intracellular magnesium
E Schmidt, C Narangoda, W Nörenberg… - Cellular and Molecular …, 2022 - Springer
Abstract Zn2+, Mg2+ and Ca2+ are essential divalent cations implicated in many metabolic
processes and signalling pathways. An emerging new paradigm is that the organismal …
processes and signalling pathways. An emerging new paradigm is that the organismal …