Over the past decade, non-coding RNA-based therapeutics have proven as a great potential
for the development of targeted therapies for cancer and other diseases. The discovery of …

Since the discovery of the first microRNAs (miRNAs, miRs), the understanding of miRNA
biology has expanded substantially. miRNAs are involved and described as master …

A major mitochondrial enzyme for protecting cells from acetaldehyde toxicity is aldehyde
dehydrogenase 2 (ALDH2). The correlation between ALDH2 dysfunction and …

MicroRNAs (miRNAs) are critical mediators of posttranscriptional regulation via their
targeting of the imperfect antisense complementary regions of coding and non-coding …

TRPM7, a divalent cation-selective channel with kinase domains, has been widely reported
to potentially affect cancers. In this study, we conducted multiple bioinformatic analyses …

Abstract Background Forkhead box M1 (FOXM1) is a proliferation-associated transcription
factor of the forkhead box proteins superfamily, which includes four isoforms FOXM1a, b, c …

Abstract MicroRNA-34 (miR-34) plays central roles in human diseases, especially cancers.
Inactivation of miR-34 is detected in cancer cell lines and tumor tissues versus normal …

Oxidative stress (OS), characterized by the excessive accumulation of reactive oxygen
species (ROS), is an emerging hallmark of cancer. Tumorigenesis and development driven …

MicroRNA (miRNA) has been widely used as an effective gene drug for tumor therapy, but
its chemical instability limited its therapeutic application in vivo. In this research, we fabricate …

Regulation of protein synthesis makes a major contribution to post-transcriptional control
pathways. During disease, or under stress, cells initiate processes to reprogramme protein …