Staphylococcus epidermidis and its dual lifestyle in skin health and infection

MM Severn, AR Horswill - Nature Reviews Microbiology, 2023 - nature.com
The coagulase-negative bacterium Staphylococcus epidermidis is a member of the human
skin microbiota. S. epidermidis is not merely a passive resident on skin but actively primes …

Staphylococcal trafficking and infection—from 'nose to gut'and back

EJM Raineri, D Altulea… - FEMS microbiology …, 2022 - academic.oup.com
Staphylococcus aureus is an opportunistic human pathogen, which is a leading cause of
infections worldwide. The challenge in treating S. aureus infection is linked to the …

Commensal production of a broad-spectrum and short-lived antimicrobial peptide polyene eliminates nasal Staphylococcus aureus

BO Torres Salazar, T Dema, NA Schilling, D Janek… - Nature …, 2024 - nature.com
Antagonistic bacterial interactions often rely on antimicrobial bacteriocins, which attack only
a narrow range of target bacteria. However, antimicrobials with broader activity may be …

Invasive Staphylococcus epidermidis uses a unique processive wall teichoic acid glycosyltransferase to evade immune recognition

Y Guo, X Du, J Krusche, C Beck, S Ali, A Walter… - Science …, 2023 - science.org
Staphylococcus epidermidis expresses glycerol phosphate wall teichoic acid (WTA), but
some health care–associated methicillin-resistant S. epidermidis (HA-MRSE) clones …

[HTML][HTML] Phage susceptibility determinants of the opportunistic pathogen Staphylococcus epidermidis

C Beck, J Krusche, AMA Elsherbini, X Du… - Current Opinion in …, 2024 - Elsevier
Highlights•Temperate phages of Staphylococcus epidermidis facilitate horizontal gene
transfer.•Wall teichoic acid glycosylation determines binding of S. epidermidis phages.•The …

Multi-species host range of staphylococcal phages isolated from wastewater

PC Göller, T Elsener, D Lorgé, N Radulovic… - Nature …, 2021 - nature.com
The host range of bacteriophages defines their impact on bacterial communities and
genome diversity. Here, we characterize 94 novel staphylococcal phages from wastewater …

Look Who's Talking: Host and Pathogen Drivers of Staphylococcus epidermidis Virulence in Neonatal Sepsis

IA Joubert, M Otto, T Strunk, AJ Currie - International journal of molecular …, 2022 - mdpi.com
Preterm infants are at increased risk for invasive neonatal bacterial infections. S.
epidermidis, a ubiquitous skin commensal, is a major cause of late-onset neonatal sepsis …

[HTML][HTML] Insights into the role of the respiratory tract microbiome in defense against bacterial pneumonia

ZG Drigot, SE Clark - Current opinion in microbiology, 2024 - Elsevier
Highlights•Obligate anaerobes in the lung improve protection against pneumonia.•Gram-
positive bacteria in the nasal cavity correlate with reduced infection risk.•Within-genus …

Modulation of MRSA virulence gene expression by the wall teichoic acid enzyme TarO

Y Lu, F Chen, Q Zhao, Q Cao, R Chen, H Pan… - Nature …, 2023 - nature.com
Phenol-soluble modulins (PSMs) and Staphylococcal protein A (SpA) are key virulence
determinants for community-associated methicillin-resistant Staphylococcus aureus (CA …

Wall teichoic acid substitution with glucose governs phage susceptibility of Staphylococcus epidermidis

C Beck, J Krusche, A Notaro, A Walter, L Kränkel… - Mbio, 2024 - Am Soc Microbiol
The species-and clone-specific susceptibility of Staphylococcus cells for bacteriophages is
governed by the structures and glycosylation patterns of wall teichoic acid (WTA) …