[HTML][HTML] Regulation of platelet activation and coagulation and its role in vascular injury and arterial thrombosis
M Tomaiuolo, LF Brass, TJ Stalker - Interventional cardiology …, 2017 - ncbi.nlm.nih.gov
Hemostasis requires the tightly regulated interaction of the coagulation system, platelets,
other blood cells and components of the vessel wall at a site of vascular injury. The …
other blood cells and components of the vessel wall at a site of vascular injury. The …
[HTML][HTML] Platelet signaling: a complex interplay between inhibitory and activatory networks
The role of platelets in hemostasis and thrombosis is dependent on a complex balance of
activatory and inhibitory signaling pathways. Inhibitory signals released from the healthy …
activatory and inhibitory signaling pathways. Inhibitory signals released from the healthy …
A systems approach to hemostasis: 1. The interdependence of thrombus architecture and agonist movements in the gaps between platelets
Hemostatic thrombi develop a characteristic architecture in which a core of highly activated
platelets is covered by a shell of less-activated platelets. Here we have used a systems …
platelets is covered by a shell of less-activated platelets. Here we have used a systems …
A systems approach to hemostasis: 3. Thrombus consolidation regulates intrathrombus solute transport and local thrombin activity
Hemostatic thrombi formed after a penetrating injury have a distinctive structure in which a
core of highly activated, closely packed platelets is covered by a shell of less-activated …
core of highly activated, closely packed platelets is covered by a shell of less-activated …
The biophysics and mechanics of blood from a materials perspective
Cells actively interact with their microenvironment, constantly sensing and modulating
biochemical and biophysical signals. Blood comprises a variety of non-adherent cells that …
biochemical and biophysical signals. Blood comprises a variety of non-adherent cells that …
[HTML][HTML] New paradigms in sepsis: from prevention to protection of failing microcirculation
J Hawiger, RA Veach, J Zienkiewicz - Journal of Thrombosis and …, 2015 - Elsevier
Sepsis, also known as septicemia, is one of the 10 leading causes of death worldwide. The
rising tide of sepsis due to bacterial, fungal and viral infections cannot be stemmed by …
rising tide of sepsis due to bacterial, fungal and viral infections cannot be stemmed by …
A three-dimensional phase-field model for multiscale modeling of thrombus biomechanics in blood vessels
Mechanical interactions between flowing and coagulated blood (thrombus) are crucial in
dictating the deformation and remodeling of a thrombus after its formation in hemostasis. We …
dictating the deformation and remodeling of a thrombus after its formation in hemostasis. We …
Energy metabolism in platelets fuels thrombus formation: halting the thrombosis engine with small-molecule modulators of platelet metabolism
Platelets are circulating cells central to haemostasis that follows vessel injury, as well as
thrombosis that ensues as a consequence of pathological stasis or plaque rupture. Platelet …
thrombosis that ensues as a consequence of pathological stasis or plaque rupture. Platelet …
Translational implications of platelets as vascular first responders
RC Becker, T Sexton, SS Smyth - Circulation research, 2018 - Am Heart Assoc
Platelets play a vital role in normal hemostasis to stem blood loss at sites of vascular injury
by tethering and adhering to sites of injury, recruiting other platelets and blood cells to the …
by tethering and adhering to sites of injury, recruiting other platelets and blood cells to the …
Temporal roles of platelet and coagulation pathways in collagen-and tissue factor-induced thrombus formation
In hemostasis and thrombosis, the complex process of thrombus formation involves different
molecular pathways of platelet and coagulation activation. These pathways are considered …
molecular pathways of platelet and coagulation activation. These pathways are considered …