Accumulating evidence suggests that epigenetic mechanisms may hold great potential in
the field of pain. We systematically reviewed the literature exploring epigenetic mechanisms …

Chronic pain is a major burden for the society and remains more prevalent and severe in
females. The presence of chronic pain is linked to persistent alterations in the peripheral and …

Inosine is a dietary supplement that is widely used for managing numerous central
neurological disorders. Interestingly, recent experimental investigation of inosine revealed …

Hyperexcitability of peripheral nociceptive pathways is often associated with inflammation
and is an important mechanism underlying inflammatory pain. Here we describe a …

Transient receptor potential vanilloid type 1 (TRPV1), a ligand-gated cation channel, is a
polymodal nocitransducer widely expressed within pain transmitting/modulating areas of the …

Introduction Protein kinase type C-ε (PKCε) plays an important role in the sensitization of
primary afferent nociceptors, promoting mechanical hyperalgesia. In accordance, we …

LPS has been widely used to induce inflammatory pain, attributing to production of
inflammatory cytokines and sensitization of nociceptors. Paeoniflorin (PF) possesses anti …

Transient receptor potential vanilloid I (TRPV1) sensitization in peripheral nociceptors is a
prominent phenomenon that occurs in inflammatory pain conditions. Pro-algesic agents can …

Chronic pain is a major health concern affecting 80million Americans at some time in their
lives with significant associated morbidity and effects on individual quality of life. Chronic …

Chronic pain is a major health concern with up to 50% of patients finding little if any relief
following traditional pharmacotherapy. This review describes the treatment of chronic pain …