The rise of a novel classification system for endometrial carcinoma; integration of molecular subclasses

J McAlpine, A Leon‐Castillo… - The Journal of pathology, 2018 - Wiley Online Library
Endometrial cancer is a clinically heterogeneous disease and it is becoming increasingly
clear that this heterogeneity may be a function of the diversity of the underlying molecular …

New classification of endometrial cancers: the development and potential applications of genomic-based classification in research and clinical care

A Talhouk, JN McAlpine - Gynecologic oncology research and practice, 2016 - Springer
Endometrial carcinoma (EC) is the fourth most common cancer in women in the developed
world. Classification of ECs by histomorphologic criteria has limited reproducibility and …

A clinically applicable molecular-based classification for endometrial cancers

A Talhouk, MK McConechy, S Leung… - British journal of …, 2015 - nature.com
Background: Classification of endometrial carcinomas (ECs) by morphologic features is
inconsistent, and yields limited prognostic and predictive information. A new system for …

Molecular classification of endometrial carcinoma on diagnostic specimens is highly concordant with final hysterectomy: earlier prognostic information to guide …

A Talhouk, LN Hoang, MK McConechy… - Gynecologic …, 2016 - Elsevier
Objective Categorization and risk stratification of endometrial carcinomas is inadequate;
histomorphologic assessment shows considerable interobserver variability, and risk of …

[HTML][HTML] Grade and estrogen receptor expression identify a subset of no specific molecular profile endometrial carcinomas at a very low risk of disease-specific death

A Jamieson, J Huvila, D Chiu, EF Thompson, S Scott… - Modern Pathology, 2023 - Elsevier
Endometrial carcinoma (EC) can be divided into 4 prognostic molecular subtypes, and no
specific molecular profile (NSMP) type is the most commonly occurring type (∼ 50%) …

Accuracy of endometrial sampling in endometrial carcinoma: a systematic review and meta-analysis

NCM Visser, C Reijnen, LFAG Massuger… - Obstetrics & …, 2017 - journals.lww.com
OBJECTIVE: To assess the agreement between preoperative endometrial sampling and
final diagnosis for tumor grade and subtype in patients with endometrial carcinoma. DATA …

Endometrial carcinoma molecular subtype correlates with the presence of lymph node metastases

A Jamieson, EF Thompson, J Huvila, S Leung… - Gynecologic …, 2022 - Elsevier
Background The role of lymph node assessment/dissection (LND) in endometrial cancer
(EC) has been debated for decades, with significant practice variation between centers …

High concordance of molecular tumor alterations between pre-operative curettage and hysterectomy specimens in patients with endometrial carcinoma

E Stelloo, RA Nout, LCLM Naves, NT Ter Haar… - Gynecologic …, 2014 - Elsevier
Objective Molecular alterations in endometrial cancer have been shown to be prognostically
significant but have not yet been implemented in the current clinical risk assessment. Few …

Relevance of sentinel lymph node procedure for patients with high-risk endometrial cancer

I Naoura, G Canlorbe, S Bendifallah, M Ballester… - Gynecologic …, 2015 - Elsevier
Objective While the accuracy of the Sentinel Lymph Node (SLN) procedure has been
validated in patients with early-stage endometrial cancer (EC) at low and intermediate risk of …

[HTML][HTML] Genetic analysis of uterine aspirates improves the diagnostic value and captures the intra-tumor heterogeneity of endometrial cancers

A Mota, E Colás, P García-Sanz, I Campoy… - Modern Pathology, 2017 - Elsevier
Endometrial cancer is the most common cancer of the female genital tract in developed
countries. Although the majority of endometrial cancers are diagnosed at early stages and …