[HTML][HTML] Targeting breast cancer stem cells
The potential roles of breast cancer stem cells (BCSCs) in tumor initiation and recurrence
have been recognized for many decades. Due to their strong capacity for self-renewal and …
have been recognized for many decades. Due to their strong capacity for self-renewal and …
Channeling the force: Piezo1 mechanotransduction in cancer metastasis
Cancer metastasis is one of the leading causes of death worldwide, motivating research into
identifying new methods of preventing cancer metastasis. Recently there has been …
identifying new methods of preventing cancer metastasis. Recently there has been …
MAPK1 promotes the metastasis and invasion of gastric cancer as a bidirectional transcription factor
Abstract Background The Mitogen-activated protein kinase 1 (MAPK1) has both
independent functions of phosphorylating histones as a kinase and directly binding the …
independent functions of phosphorylating histones as a kinase and directly binding the …
Identification of cell type–specific correlations between ERK activity and cell viability upon treatment with ERK1/2 inhibitors
TD Lebedev, ER Khabusheva, SR Mareeva… - Journal of Biological …, 2022 - ASBMB
Increased MAPK signaling is a hallmark of various cancers and is a central regulator of cell
survival. Direct ERK1/2 inhibition is considered a promising approach to avoid ERK1/2 …
survival. Direct ERK1/2 inhibition is considered a promising approach to avoid ERK1/2 …
SNAI1-mediated transcriptional regulation of epithelial-to-mesenchymal transition genes in breast cancer stem cells
Background Triple-negative breast cancer (TNBC) tumors are composed of a
heterogeneous population containing both cancer cells and cancer stem cells (CSCs) …
heterogeneous population containing both cancer cells and cancer stem cells (CSCs) …
Lactate receptor GPR81 drives breast cancer growth and invasiveness through regulation of ECM properties and Notch ligand DLL4
K Lundø, O Dmytriyeva, L Spøhr, E Goncalves-Alves… - BMC cancer, 2023 - Springer
Background The lactate receptor GPR81 contributes to cancer development through unclear
mechanisms. Here, we investigate the roles of GPR81 in three-dimensional (3D) and in vivo …
mechanisms. Here, we investigate the roles of GPR81 in three-dimensional (3D) and in vivo …
Enhanced therapeutic effect of optimized melittin-dKLA, a peptide agent targeting M2-like tumor-associated macrophages in triple-negative breast cancer
S Kim, I Choi, IH Han, H Bae - International Journal of Molecular Sciences, 2022 - mdpi.com
Triple-negative breast cancer (TNBC) is characterized by a high possibility of metastasis. M2-
like tumor-associated macrophages (TAMs) are the main components of the tumor …
like tumor-associated macrophages (TAMs) are the main components of the tumor …
[HTML][HTML] Exosomes modified with anti-MEK1 siRNA lead to an effective silencing of triple negative breast cancer cells
Triple negative breast cancer (TNBC) is a highly heterogenous disease not sensitive to
endocrine or HER2 therapy and standardized treatment regimens are still missing …
endocrine or HER2 therapy and standardized treatment regimens are still missing …
[HTML][HTML] Progestins and breast cancer hallmarks: The role of the ERK1/2 and JNK pathways in estrogen receptor positive breast cancer cells
R Louw-du Toit, M Simons, D Africander - The Journal of Steroid …, 2024 - Elsevier
Progestins used in hormonal contraceptives and menopausal hormone therapy (MHT) have
been linked to increased breast cancer risk. Whether the association holds for all progestins …
been linked to increased breast cancer risk. Whether the association holds for all progestins …
Characterization of the circRNA–miRNA–mRNA network to reveal the potential functional ceRNAs associated with dynamic changes in the meat quality of the …
G Bao, F Zhao, J Wang, X Liu, J Hu, B Shi… - Frontiers in veterinary …, 2022 - frontiersin.org
Circular RNAs (circRNAs) have a regulatory role in animal skeletal muscle development. In
this study, RNA sequencing was performed to reveal the temporal regularity of circRNA …
this study, RNA sequencing was performed to reveal the temporal regularity of circRNA …