Single-cell RNA sequencing (scRNA-seq) technologies allow the dissection of gene
expression at single-cell resolution, which greatly revolutionizes transcriptomic studies. A …

Recent technological advancements have enabled the profiling of a large number of
genome-wide features in individual cells. However, single-cell data present unique …

Annotating cell types on the basis of single-cell RNA-seq data is a prerequisite for research
on disease progress and tumour microenvironments. Here we show that existing annotation …

SARS-CoV-2 infection can cause severe respiratory COVID-19. However, many individuals
present with isolated upper respiratory symptoms, suggesting potential to constrain viral …

Lupus nephritis is a potentially fatal autoimmune disease for which the current treatment is
ineffective and often toxic. To develop mechanistic hypotheses of disease, we analyzed …

Single-cell RNA sequencing (scRNA-seq) data are commonly affected by technical artifacts
known as" doublets," which limit cell throughput and lead to spurious biological conclusions …

Differential expression analysis in single-cell transcriptomics enables the dissection of cell-
type-specific responses to perturbations such as disease, trauma, or experimental …

Immunotherapy is a promising treatment for triple-negative breast cancer (TNBC), but
patients relapse, highlighting the need to understand the mechanisms of resistance. We …

Besides cardiomyocytes (CM), the heart contains numerous interstitial cell types which play
key roles in heart repair, regeneration and disease, including fibroblast, vascular and …

The diversity of cell types and regulatory states in the brain, and how these change during
aging, remains largely unknown. We present a single-cell transcriptome atlas of the entire …