Gold complexes in anticancer therapy: From new design principles to particle‐based delivery systems

G Moreno‐Alcántar, P Picchetti… - Angewandte Chemie …, 2023 - Wiley Online Library
The discovery of the medicinal properties of gold complexes has fuelled the design and
synthesis of new anticancer metallodrugs, which have received special attention due to their …

A focus on the biological targets for coinage metal-NHCs as potential anticancer complexes

F Guarra, A Pratesi, C Gabbiani, T Biver - Journal of Inorganic Biochemistry, 2021 - Elsevier
Metal complexes of N-heterocyclic carbene (NHC) ligands are the object of increasing
attention for therapeutic purposes. Among the different metal centres, interest on Au-based …

Rationally designed redox-active Au (I) N-heterocyclic carbene: an immunogenic cell death inducer

S Sen, S Hufnagel, EY Maier, I Aguilar… - Journal of the …, 2020 - ACS Publications
Immunogenic cell death (ICD) is a way of reengaging the tumor-specific immune system.
ICD can be induced by treatment with chemotherapeutics. However, only a limited number …

A novel Mn–Cu bimetallic complex for enhanced chemodynamic therapy with simultaneous glutathione depletion

S Cao, J Fan, W Sun, F Li, K Li, X Tai… - Chemical …, 2019 - pubs.rsc.org
A bimetallic complex, containing Mn (II) and Cu (II) moieties, was synthesized for
chemodynamic therapy (CDT) of cancer. The complex was capable of generating a hydroxyl …

Making aggregation-induced emission luminogen more valuable by gold: enhancing anticancer efficacy by suppressing thioredoxin reductase activity

H Zou, J Zhang, C Wu, B He, Y Hu, HHY Sung… - ACS …, 2021 - ACS Publications
Gold complexes have been recognized as potential anticancer agents against various kinds
of diseases due to their inherent suppressions of antioxidant thioredoxin reductase (TrxR) …

The anti-breast cancer stem cell properties of gold (I)-non-steroidal anti-inflammatory drug complexes

A Johnson, C Olelewe, JH Kim, J Northcote-Smith… - Chemical …, 2023 - pubs.rsc.org
The anti-breast cancer stem cell (CSC) properties of a series of gold (I) complexes
comprising various non-steroidal anti-inflammatory drugs (NSAIDs) and triphenylphosphine …

Reaction Behavior of [1,3-Diethyl-4,5-diphenyl-1H-imidazol-2-ylidene] Containing Gold(I/III) Complexes against Ingredients of the Cell Culture Medium and the …

P Kapitza, A Scherfler, S Salcher… - Journal of Medicinal …, 2023 - ACS Publications
The reactivities of halido [1, 3-diethyl-4, 5-diphenyl-1 H-imidazol-2-ylidene] gold (I)(chlorido
(5), bromido (6), iodido (7)), bis [1, 3-diethyl-4, 5-diphenyl-1 H-imidazol-2-ylidene] gold (I)(8) …

Heteroleptic Gold (I)-bisNHC complex with excellent activity in vitro, ex vivo and in vivo against endometrial cancer

Q Xiao, Y Liu, G Jiang, Y Liu, Y Huang, W Liu… - European Journal of …, 2022 - Elsevier
Endometrial cancer (EC), one of the most common gynaecologic malignancies, can
seriously impair female health. Although great advances in EC therapy have been achieved …

Naphthalimide-NHC complexes: Synthesis and properties in catalytic, biological and photophysical applications

L Roos, FP Malan, M Landman - Coordination Chemistry Reviews, 2021 - Elsevier
The following review provides an account of all 82 N-heterocyclic carbene metal complexes
containing a naphthalimide-NHC moiety, incorporating either an imidazolylidene …

Metal N-heterocyclic carbene complexes as potential metallodrugs in antitumor therapy

YF Zhang, YK Yin, H Zhang, YF Han - Coordination Chemistry Reviews, 2024 - Elsevier
Metal complexes, which exhibit alterable oxidation states, coordination numbers, and
capacity to coordinate with different ligands, have provided a versatile platform for designing …