Despite their first recognition almost 40 years ago, CD8+'suppressor'T cells remain poorly
characterized. Recent studies of these lymphocytes, now popularly referred to as regulatory …

Autoimmune disease results from the dysregulation of basic tolerogenic processes designed
to control self/non-self-discrimination. Approaches to treat autoimmunity have focused …

Modified anti-CD3 mAbs are emerging as a possible means of inducing immunologic
tolerance in settings including transplantation and autoimmunity such as in type 1 diabetes …

Abstract Immune regulatory CD4+ CD25+ T cells play a crucial role in inducing and
maintaining allograft tolerance in experimental models of transplantation (Tx). In humans …

Background. A bilateral hand allotransplantation was performed in a patient six years ago.
Whereas skin is known to be highly immunogenic, grafts have been well accepted up to …

Dietary intake of omega-3 polyunsaturated fatty acids (PUFAs) has been found to affect
inflammation and metabolism, and many researchers have shown that omega-3 PUFAs …

Background For the clinical applicability of regulatory T cells (Tregs) in transplantation, it is
critical to determine if donor antigen specificity is required for their immunosuppressive …

Regulatory T cells are considered to be pivotal for the induction of tolerance to donor
antigens. In the past decades, several regulatory T-cell subsets have been identified, such …

The field of biomarker discovery made a significant leap over the past few decades. As we
enter the Era of the Human Genome, thousands of biomarkers can be identified in a …

A series of 15-mer peptides were synthesized defining continuous sequences of the
extracellular region of the murine and human CD200 molecule. In addition, peptides …