High-grade neuroendocrine neoplasms (HG-NENs) are clinically aggressive diseases, the
classification of which has recently been redefined. They now include both poorly …

Simple Summary Isocitrate dehydrogenase 1 and 2 (IDH1 and IDH2) are essential
metabolic enzymes involved in the tricarboxylic acid (TCA) cycle. Several mutations in IDH …

Abstract The 5-methylcytosine (m5C) RNA methyltransferase NSUN2 is involved in the
regulation of cell proliferation and metastasis formation and is upregulated in multiple …

The diagnosis of sinonasal tumors is challenging due to a heterogeneous spectrum of
various differential diagnoses as well as poorly defined, disputed entities such as sinonasal …

Small-cell lung cancer (SCLC) is the most aggressive and lethal subtype of lung cancer, for
which, better understandings of its biology are urgently needed. Single-cell sequencing …

The molecular pathogenesis of poorly differentiated sinonasal carcinoma received
significant attention in recent years. As a consequence, several unclassified carcinomas in …

Tumor-associated macrophages (TAMs) play an important role in remodeling the tumor
microenvironment (TME), which promotes tumor growth, immunosuppression and …

Background The outcome of hepatocellular carcinoma (HCC) is limited by its complex
molecular characteristics and changeable tumor microenvironment (TME). Here we focused …

Molecular analysis has reshaped the landscape of high grade sinonasal tumors by defining
novel entities and identifying recurrent mutations in established tumor types. However …

Background Invasive adenocarcinoma (IAC), which is typically preceded by minimally
invasive adenocarcinoma (MIA), is the dominant pathological subtype of early-stage lung …