Sp1-like proteins and Krüppel-like factors (KLFs) are highly related zinc-finger proteins that
are important components of the eukaryotic cellular transcriptional machinery. By regulating …

GC-boxes and related motifs are frequently occurring DNA-elements present in many
promoters and enhancers. In contrast to other elements it was generally thought that the …

The receptor for advanced glycation end products (RAGE), a multi-ligand member of the
immunoglobulin superfamily of cell surface molecules,, interacts with distinct molecules …

Gap genes are involved in segment determination during the early development of the fruit
fly Drosophila melanogaster as well as in other insects. This review attempts to synthesize …

A major challenge in interpreting genome sequences is understanding how the genome
encodes the information that specifies when and where a gene will be expressed. The first …

The advent of the genome projects has provided new avenues to explore the question of
how DNA sequence information is used appropriately by mammalian cells. Regulation of …

The initiation of transcription is accomplished via interactions of many different proteins with
common and gene-specific regulatory motifs. Clearly, sequence-specific transcription factors …

Dopamine receptor genes are under complex transcription control, determining their unique
regional distribution in the brain. We describe here a zinc finger type transcription factor …

The transcription factor SP1 contains three Krüppel-like zinc fingers. Recently, several
related proteins, including erythroid, lung and gut-enriched Krüppel-like factors, have been …

Spl is one of the very first cellular transcription factors to be identified and cloned in virtue of
its binding to a Grich motif in the SV40 early promoter. Spl protein binds to the Grich …