The link between relative stability constant of DNA-and BSA-chromenopyrimidine complexes and cytotoxicity towards human breast cancer cells (MCF-7)

SJ Zamisa, AA Adeleke, N Devnarain, MA Rhman… - RSC …, 2023 - pubs.rsc.org
In this study, we synthesized and characterized ten chromenopyrimidine derivatives using
analytical and spectroscopic methods. Studies on DNA and albumin binding affinity, as well …

DNA/BSA binding studies and in vitro anticancer and antibacterial studies of isoelectronic Cu (I)-and Ag (I)-pyridinyl Schiff base complexes incorporating …

AA Adeleke, SD Oladipo, SJ Zamisa, IA Sanusi… - Inorganica Chimica …, 2023 - Elsevier
Four mononuclear Ag (I) and Cu (I) Schiff base complexes of the type [M (L)(PPh 3) 2] X
[where M= Ag+ or Cu+, L=(E)-N-(2-fluorophenyl)-1-(pyridin-2-yl) methanimine (fpm) or (E)-1 …

Silver (I) pyridinyl complexes with benzothiazole, thiophene, and furan moieties: DNA/protein‐binding, antibacterial, antioxidant, and anticancer studies

AA Adeleke, MS Islam, B Omondi - Archiv der Pharmazie, 2023 - Wiley Online Library
We have synthesized and characterized nine Ag (I) complexes of Schiff bases containing
thiophene, furan, and pyridine moieties for in vitro antibacterial, antioxidant, anticancer …

Mononuclear discrete Ag (I) complexes of aryl substituted (E)-N-phenyl-1-(pyridin-3-yl) methanimine: In vitro biological activities and interactions with biomolecules

AA Adeleke, MS Islam, K Olofinsan, VF Salau… - South African Journal …, 2023 - scielo.org.za
The synthesis of three pyridinyl imines (L1-L3) with electron-donating and electron-
withdrawing functional groups, as well as their silver (I) complexes (1a-3a, 1b-3b and 1c-3c) …

[HTML][HTML] Structural studies of racemic and diastereomeric 2-amino-3-carbonitrile-based chromene derivatives

PN Ngubane, T Papo, S Zamisa, B Omondi - Journal of Molecular Structure, 2025 - Elsevier
In this study, we present a comprehensive exploration of sixteen novel 2-amino-4-aryl-5-oxo-
5, 6, 7, 8-tetrahydro-4H-chromene-3-carbonitriles synthesized through a streamlined …

Design, synthesis, structural investigation and binding study of 2-pyridone-based pharmaceutical precursor with DNA

J Dowarah, B Hazarika, BS Sran, D Khiangte… - Journal of Molecular …, 2023 - Elsevier
Natural pyridones/pyridines and synthetic derivatives have shown different bio-activities and
binding affinities with different receptors. Herein, we present the synthesis of four pyridone …

[HTML][HTML] Synthesis, characterization, and antibacterial activity of functionalized terpyridine silver (I) complexes

ML Pillay, B Omondi, AA Adeleke, S Jonnalaggada… - Results in …, 2024 - Elsevier
Abstract Eight terpyridine ligands, 4′-methoxy-2, 2′: 6′, 2 ″-terpyridine (L1), 2′-
methoxy-2, 2′: 6′, 2 ″-terpyridine (L2), 4′-hydroxyl-2, 2′: 6′, 2 ″-terpyridine (L3), 4 …

Synthesis and Therapeutic Potential of selected Schiff Bases: In vitro Antibacterial, Antioxidant, Antidiabetic, and Computational Studies

AA Adeleke, SD Oladipo, RC Luckay… - …, 2024 - Wiley Online Library
In this study, three Schiff base compounds,(E)‐N‐(4‐bromophenyl)‐1‐(2‐nitrophenyl)
methanimine (L1),(E)‐2‐((mesitylimino) methyl) phenol (L2), and (E)‐N‐(4‐bromophenyl)‐1 …

[HTML][HTML] 2-Amino-5-oxo-4-(thiophen-2-yl)-5, 6, 7, 8-tetrahydro-4H-chromene-3-carbonitrile

C Nyapola, SJ Zamisa, EM Njogu, B Omondi - IUCrData, 2024 - journals.iucr.org
The crystal structure of the title compound, C14H12N2O2S, reveals two symmetrically
independent molecules within the asymmetric unit. Each molecule contains a chromenone …