Challenges of intervention, treatment, and antibiotic resistance of biofilm-forming microorganisms

G Gebreyohannes, A Nyerere, C Bii, DB Sbhatu - Heliyon, 2019 - cell.com
Background Biofilms are multicellular communities of microorganisms held together by a self-
produced extracellular matrix. The ability of microbes to form biofilm is a universal …

The Prevalence of Adherent-Invasive Escherichia coli and Its Association With Inflammatory Bowel Diseases: A Systematic Review and Meta-Analysis

R Kamali Dolatabadi, A Feizi, M Halaji, H Fazeli… - Frontiers in …, 2021 - frontiersin.org
Inflammatory bowel diseases (IBD), including Crohn's disease (CD) and ulcerative colitis
(UC), are known as chronic gastrointestinal inflammatory disorders. The present systematic …

Short Chain Fatty Acids Modulate the Growth and Virulence of Pathosymbiont Escherichia coli and Host Response

S Zhang, B Dogan, C Guo, D Herlekar, K Stewart… - Antibiotics, 2020 - mdpi.com
Short chain fatty acids (SCFA), principally acetate, propionate, and butyrate, are produced
by fermentation of dietary fibers by the gut microbiota. SCFA regulate the growth and …

The Crohn's disease-related bacterial strain LF82 assembles biofilm-like communities to protect itself from phagolysosomal attack

V Prudent, G Demarre, E Vazeille, M Wery… - Communications …, 2021 - nature.com
Patients with Crohn's disease exhibit abnormal colonization of the intestine by adherent
invasive E. coli (AIEC). They adhere to epithelial cells, colonize them and survive inside …

Prevalence, Abundance, and Virulence of Adherent-Invasive Escherichia coli in Ulcerative Colitis, Colorectal Cancer, and Coeliac Disease

M López-Siles, C Camprubí-Font… - Frontiers in …, 2022 - frontiersin.org
Background & Aims Adherent-invasive E. coli (AIEC) has largely been implicated in the
pathogenesis of Crohn's disease (CD). E. coli strains with similar genetic backgrounds and …

Blockage of bacterial FimH prevents mucosal inflammation associated with Crohn's disease

G Chevalier, A Laveissière, G Desachy, N Barnich… - Microbiome, 2021 - Springer
Abstract Background An Escherichia coli (E. coli) pathotype with invasive properties, first
reported by Darfeuille-Michaud and termed adherent-invasive E. coli (AIEC), was shown to …

Companion Animals as Potential Reservoirs of Antibiotic Resistant Diarrheagenic Escherichia coli in Shandong, China

L Cui, X Zhao, R Li, Y Han, G Hao, G Wang, S Sun - Antibiotics, 2022 - mdpi.com
Antibiotic resistance genes of Escherichia coli (E. coli) from companion animals were still
poorly understood. Here, we investigated the extended-spectrum β-lactamases (ESBLs) …

Identification of differences in gene expression implicated in the Adherent-Invasive Escherichia coli phenotype during in vitro infection of intestinal epithelial cells

Q Bonet-Rossinyol, C Camprubí-Font… - Frontiers in Cellular …, 2023 - frontiersin.org
Introduction Adherent-invasive Escherichia coli (AIEC) is strongly associated with the
pathogenesis of Crohn's disease (CD). However, no molecular markers currently exist for …

Molecular Characteristics of ST1193 Clone among Phylogenetic Group B2 Non-ST131 Fluoroquinolone-Resistant Escherichia coli

J Wu, F Lan, Y Lu, Q He, B Li - Frontiers in Microbiology, 2017 - frontiersin.org
Objectives: Sequence type 1193 is emerging as a new, virulent and resistant lineage among
fluoroquinolone resistant Escherichia coli (FQr E. coli). In this study, we investigated the …

Safety, pharmacokinetic, and pharmacodynamic study of sibofimloc, a novel FimH blocker in patients with active Crohn's disease

W Reinisch, X Hébuterne, A Buisson… - Journal of …, 2022 - Wiley Online Library
Abstract Background and Aim Expression of FimH adhesin by invasive Escherichia coli in
the gastrointestinal tract of patients with Crohn's disease (CD) facilitates binding to epithelial …