A guide to machine learning for biologists
The expanding scale and inherent complexity of biological data have encouraged a growing
use of machine learning in biology to build informative and predictive models of the …
use of machine learning in biology to build informative and predictive models of the …
Enzymology of assembly line synthesis by modular polyketide synthases
M Grininger - Nature Chemical Biology, 2023 - nature.com
Modular polyketide synthases (PKSs) run catalytic reactions over dozens of steps in a highly
orchestrated manner. To accomplish this synthetic feat, they form megadalton multienzyme …
orchestrated manner. To accomplish this synthetic feat, they form megadalton multienzyme …
ProtGPT2 is a deep unsupervised language model for protein design
Protein design aims to build novel proteins customized for specific purposes, thereby
holding the potential to tackle many environmental and biomedical problems. Recent …
holding the potential to tackle many environmental and biomedical problems. Recent …
Design of protein-binding proteins from the target structure alone
The design of proteins that bind to a specific site on the surface of a target protein using no
information other than the three-dimensional structure of the target remains a challenge …
information other than the three-dimensional structure of the target remains a challenge …
Genomic characterization of the 2019 novel human-pathogenic coronavirus isolated from a patient with atypical pneumonia after visiting Wuhan
ABSTRACT A mysterious outbreak of atypical pneumonia in late 2019 was traced to a
seafood wholesale market in Wuhan of China. Within a few weeks, a novel coronavirus …
seafood wholesale market in Wuhan of China. Within a few weeks, a novel coronavirus …
flDPnn: Accurate intrinsic disorder prediction with putative propensities of disorder functions
G Hu, A Katuwawala, K Wang, Z Wu… - Nature …, 2021 - nature.com
Identification of intrinsic disorder in proteins relies in large part on computational predictors,
which demands that their accuracy should be high. Since intrinsic disorder carries out a …
which demands that their accuracy should be high. Since intrinsic disorder carries out a …
Developing a fully glycosylated full-length SARS-CoV-2 spike protein model in a viral membrane
This technical study describes all-atom modeling and simulation of a fully glycosylated full-
length SARS-CoV-2 spike (S) protein in a viral membrane. First, starting from PDB: 6VSB …
length SARS-CoV-2 spike (S) protein in a viral membrane. First, starting from PDB: 6VSB …
Nucleolar maturation of the human small subunit processome
S Singh, A Vanden Broeck, L Miller, M Chaker-Margot… - Science, 2021 - science.org
INTRODUCTION The ribosome catalyzes protein synthesis in all cells by coupling the
decoding of messenger RNA by the small ribosomal subunit with peptide bond formation by …
decoding of messenger RNA by the small ribosomal subunit with peptide bond formation by …
[HTML][HTML] Improved pathogenicity prediction for rare human missense variants
The success of personalized genomic medicine depends on our ability to assess the
pathogenicity of rare human variants, including the important class of missense variation …
pathogenicity of rare human variants, including the important class of missense variation …
DDX3X acts as a live-or-die checkpoint in stressed cells by regulating NLRP3 inflammasome
The cellular stress response has a vital role in regulating homeostasis by modulating cell
survival and death. Stress granules are cytoplasmic compartments that enable cells to …
survival and death. Stress granules are cytoplasmic compartments that enable cells to …