Molecular scaffold or adaptor proteins facilitate precise spatiotemporal regulation and
integration of multiple signaling pathways to effect the optimal cellular response to changes …

Proteins of the CAS (Crk-associated substrate) family (BCAR1/p130Cas, NEDD9/HEF1/Cas-
L, EFS/SIN and CASS4/HEPL) are integral players in normal and pathological cell biology …

Mammary tumors are a major health threat to women and female dogs. In both, metastasis of
the primary tumor to distant organs is the most common cause of tumor-related death …

Naturally occurring tumours in domestic animals have been recognized as an interesting
opportunity for comparative oncology (MacEwen, 1990; Vail & MacEwen, 2000). Cancer is …

Focal adhesion kinase (FAK) is one of the central signaling molecules found at focal
adhesion sites, which are specific areas on the cell membrane where cells attach to …

Crk-associated substrate (CAS, p130Cas) is a major tyrosine phosphorylated protein in cells
transformed by v-crk and v-src oncogenes. We recently reported that reexpression of CAS in …

Ultraviolet (UV)-photofunctionalization of titanium substantially enhances the strength and
quality of osseointegration by promoting osteogenic cellular attachment and proliferation …

Neuroblastoma is a heterogeneous tumor consisting of N (neuronal) and S (stromal) cells.
We report that more tumorigenic and motile N cells express higher levels of IGF-I receptor …

Purpose: BCAR1, the human homologue of the rat p130Cas protein, was identified in a
functional screen for human breast cancer cell proliferation resistant to antiestrogen drugs …

Aims Benign prostatic hyperplasia (BPH) is the most common urological disease that is
characterized by the excessive growth of prostatic epithelial and stromal cells …