The enhancer of zeste homolog 2 (EZH2) is encoded by the Enhancer of zeste 2 polycomb
repressive complex 2 subunit gene. EZH2 is involved in the cell cycle, DNA damage repair …

The cellular mechanisms underlying hereditary photoreceptor degeneration are still poorly
understood, a problem that is exacerbated by the enormous genetic heterogeneity of this …

Poor therapeutic outcomes of antioxidants in ophthalmologic clinical applications, including
glutathione during photoreceptor degeneration in retinitis pigmentosa (RP), are caused by …

Retinitis pigmentosa (RP) is an important cause of irreversible blindness worldwide and
lacks effective treatment strategies. Although mutations are the primary cause of RP …

Glaucoma is the world's leading irreversible blinding eye disease. Lowering intraocular
pressure is currently the only effective clinical treatment. However, there is a lack of long …

In the developing vertebrate retina, retinal progenitor cells (RPCs) proliferate and give rise to
terminally differentiated neurons with exquisite spatio-temporal precision. Lineage …

Glaucoma, a complex and multifactorial neurodegenerative disorder, is a leading cause of
irreversible blindness worldwide. Despite significant advancements in our understanding of …

Epigenetic modifiers are increasingly being investigated as potential therapeutics to modify
and overcome disease phenotypes. Diseases of the nervous system present a particular …

The function of exosomal miRNAs (miRs) in retinal degeneration is largely unclear. We were
aimed to investigate the functions of exosomes as well as their miRs derived from retinal …

Elucidation of the cellular changes that occur in degenerating photoreceptors of people with
inherited retinal diseases (IRDs) has been a focus for many research teams, leading to …