Cardiac arrhythmias are among the leading causes of mortality. They often arise from
alterations in the electrophysiological properties of cardiac cells and their underlying ionic …

Voltage-gated calcium channels are important regulators of brain, heart and muscle
functions, and their dysfunction can give rise to pathophysiological conditions ranging from …

The voltage-gated calcium (Cav) channels convert membrane electrical signals to
intracellular Ca2+-mediated events. Among the ten subtypes of Cav channel in mammals …

The heart is a rhythmic electromechanical pump, the functioning of which depends on action
potential generation and propagation, followed by relaxation and a period of refractoriness …

The detection and processing of painful stimuli in afferent sensory neurons is critically
dependent on a wide range of different types of voltage-and ligand-gated ion channels …

INTRODUCTION Voltage-gated Ca2+ (Cav) channels activate in response to membrane
potential changes and initiate Ca2+-mediated cellular signaling cascades. The L-type, high …

Calcium regulates a wide spectrum of physiological processes such as heartbeat, muscle
contraction, neuronal communication, hormone release, cell division, and gene …

The maturation of nanotechnology has revealed it to be a unique and distinct discipline
rather than a specialization within a larger field. Its textbook cannot afford to be a chemistry …

Pregabalin is an antagonist of voltage gated Ca2+ channels and specifically binds to alpha-
2-delta subunit to produce antiepileptic and analgesic actions. It successfully alleviates the …

Sydney Ringer would be overwhelmed today by the implications of his simple experiment
performed over 120 years ago showing that the heart would not beat in the absence of …