Diagnosis and management of progressive multiple sclerosis

G Macaron, D Ontaneda - Biomedicines, 2019 - mdpi.com
Multiple sclerosis is a chronic autoimmune disease of the central nervous system that results
in varying degrees of disability. Progressive multiple sclerosis, characterized by a steady …

Disease-modifying treatment in progressive multiple sclerosis

JR Ciotti, AH Cross - Current treatment options in neurology, 2018 - Springer
Purpose of review Multiple sclerosis (MS) is an immune-mediated disorder that affects the
central nervous system (CNS), often first affecting people in early adulthood. Although most …

Updates and advances in multiple sclerosis neurotherapeutics

M Amin, CM Hersh - Neurodegenerative disease management, 2023 - Taylor & Francis
The multiple sclerosis (MS) neurotherapeutic landscape is rapidly evolving. New disease-
modifying therapies (DMTs) with improved efficacy and safety, in addition to an expanding …

Clinical trials for progressive multiple sclerosis: progress, new lessons learned, and remaining challenges

J Chataway, T Williams, V Li, RA Marrie… - The Lancet …, 2024 - thelancet.com
Despite the success of disease-modifying treatments in relapsing multiple sclerosis, for
many individuals living with multiple sclerosis, progressive disability continues to accrue …

Therapeutic advances and challenges in the treatment of progressive multiple sclerosis

LE Baldassari, RJ Fox - Drugs, 2018 - Springer
Despite the fact that majority of patients with multiple sclerosis (MS) have relapsing-remitting
disease, many transition to secondary progressive disease (SPMS) over time. This transition …

Disability outcome measures in phase III clinical trials in multiple sclerosis

BMJ Uitdehaag - CNS drugs, 2018 - Springer
Accumulating neurological disability has a substantial impact on the lives of patients with
multiple sclerosis (MS). As well as the established Expanded Disability Status Scale (EDSS) …

[HTML][HTML] Brazilian consensus for the treatment of multiple sclerosis: Brazilian Academy of Neurology and Brazilian Committee on Treatment and Research in Multiple …

VD Marques, GR Passos, MF Mendes… - Arquivos de Neuro …, 2018 - SciELO Brasil
The expanding therapeutic arsenal in multiple sclerosis (MS) has allowed for more effective
and personalized treatment, but the choice and management of disease-modifying therapies …

Autologous haematopoietic stem cell transplantation versus low‐dose immunosuppression in secondary–progressive multiple sclerosis

A Mariottini, G Bulgarini, B Forci… - European Journal of …, 2022 - Wiley Online Library
Background and purpose Effectiveness of autologous haematopoietic stem cell
transplantation (AHSCT) in relapsing–remitting multiple sclerosis (MS) is well known, but in …

A potential role for cyclophosphamide in the mitigation of acute respiratory distress syndrome among patients with SARS-CoV-2

S Revannasiddaiah, SK Devadas, R Palassery… - Medical hypotheses, 2020 - Elsevier
While humanity struggles to develop a vaccine against SARS-CoV-2, it is imperative that
effective and affordable therapeutic strategies be evolved. Since a majority of the SARS-CoV …

Failed, interrupted, or inconclusive trials on immunomodulatory treatment strategies in multiple sclerosis: update 2015–2020

L Rolfes, M Pawlitzki, S Pfeuffer, N Huntemann… - BioDrugs, 2020 - Springer
In the past decades, multiple sclerosis (MS) treatment has experienced vast changes
resulting from major advances in disease-modifying therapies (DMT). Looking at the overall …