The discovery of the Janus kinase (JAK)-signal transducer and activator of transcription
(STAT) pathway arose from investigations of how cells respond to interferons (IFNs) …

Structured models of ontogenic, phenotypic and functional diversity have been instrumental
for a renewed understanding of the biology of immune cells, such as macrophages and …

Abstract Kinases of the Jak ('Janus kinase') family and transcription factors (TFs) of the STAT
('signal transducer and activator of transcription') family constitute a rapid membrane-to …

How distal cis-regulatory elements (eg, enhancers) communicate with promoters remains an
unresolved question of fundamental importance. Although transcription factors and cofactors …

Genome-wide association studies have identified loci underlying human diseases, but the
causal nucleotide changes and mechanisms remain largely unknown. Here we developed a …

Tumours progress despite being infiltrated by tumour-specific effector T cells. Tumours
contain areas of cellular necrosis, which are associated with poor survival in a variety of …

Fundamental insight gained over the last decades led to the discovery of cytokines as
pivotal drivers of inflammatory diseases such as rheumatoid arthritis, psoriasis/psoriasis …

Enhancer elements are genomic regulatory sequences that direct the selective expression
of genes so that genetically identical cells can differentiate and acquire the highly …

Type I interferons (IFNs) activate intracellular antimicrobial programmes and influence the
development of innate and adaptive immune responses. Canonical type I IFN signalling …

Following the discovery of T helper 17 (TH17) cells, the past decade has witnessed a major
revision of the TH subset paradigm and substantial progress has been made in deciphering …